{"id":"W2043260789","doi":"10.4161/15548627.2014.981915","title":"Mitochondrial damage contributes to<i>Pseudomonas aeruginosa</i>activation of the inflammasome and is downregulated by autophagy","year":2015,"lang":"en","type":"article","venue":"Autophagy","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":155,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Biotechnology and Biological Sciences Research Council; Wellcome Trust","keywords":"NLRC4; Inflammasome; Autophagy; Biology; Cell biology; AIM2; Mitochondrion; Reactive oxygen species; Mitochondrial DNA; Caspase 1; Biochemistry; Apoptosis; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001796797,0.0002633469,0.0004788709,0.0001236646,0.00009906682,0.00003428057,0.0002170105,0.0001998966,0.0001208109],"category_scores_gemma":[0.0002489458,0.0001916194,0.0001304549,0.0004819226,0.0002043028,0.0001657848,0.0001240058,0.000198955,0.00003377781],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009423379,"about_ca_system_score_gemma":0.0002569659,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000129594,"about_ca_topic_score_gemma":0.000002512756,"domain_scores_codex":[0.9982812,0.00009813355,0.0004517605,0.0003769452,0.0004557317,0.0003361701],"domain_scores_gemma":[0.9985122,0.0001073691,0.000188792,0.000614024,0.0002646106,0.0003130021],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001146894,0.0003610621,0.003642474,0.00007106311,0.0004130455,0.00002545375,0.001592687,0.00002746088,0.9234843,0.002826731,0.06238014,0.004028659],"study_design_scores_gemma":[0.005866809,0.0002979221,0.07948031,0.0001147726,0.000146417,0.00001659577,0.00008165354,0.0003528478,0.8853271,0.001879384,0.02623548,0.0002007362],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927838,0.001099091,0.0002267379,0.003441196,0.0004675477,0.0009370311,0.0000646135,0.0001029185,0.0008770545],"genre_scores_gemma":[0.9933801,0.0000274386,0.0002409988,0.003431584,0.0001877426,0.00004503216,0.00004619919,0.00003539326,0.002605543],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07583783,"threshold_uncertainty_score":0.7814012,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01123443571903489,"score_gpt":0.2522010504238168,"score_spread":0.2409666147047819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}