{"id":"W2043276366","doi":"10.1016/j.freeradbiomed.2004.10.035","title":"Mechanism of cytotoxicity of catechols and a naphthalenediol in PC12-AC cells: the connection between extracellular autoxidation and molecular electronic structure","year":2004,"lang":"en","type":"article","venue":"Free Radical Biology and Medicine","topic":"Free Radicals and Antioxidants","field":"Chemistry","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; Carleton University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Autoxidation; Cytotoxicity; Glutathione; Catechol; Hydroquinone; Antioxidant; Stereochemistry; Extracellular; Oxidative stress; Hydrogen peroxide; Biochemistry; In vitro; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001473045,0.0002667974,0.0002560187,0.0001734962,0.0001905653,0.0002861606,0.0004019358,0.0004724748,0.001297404],"category_scores_gemma":[0.0001002555,0.0001621837,0.0003308049,0.0001315373,0.0002305342,0.0003691158,0.0001502834,0.0003863471,0.0003498746],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003504296,"about_ca_system_score_gemma":0.0001707661,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009099572,"about_ca_topic_score_gemma":0.0007745915,"domain_scores_codex":[0.9999262,0.00001405728,0.000006437873,0.00001052086,0.00002145569,0.00002135538],"domain_scores_gemma":[0.9998544,0.00002996706,0.00002566403,0.00003353231,0.00003884807,0.0000175602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004991377,0.00005845099,0.0005531401,0.00009243772,0.00001871038,0.0001997354,0.00004963795,0.0001652449,0.9952661,0.0005114834,0.00007336866,0.002512507],"study_design_scores_gemma":[0.00001361645,0.0002499347,0.004544874,0.000004367264,0.00001687029,0.0002396002,0.00004080527,0.0008406112,0.993403,0.0001292444,0.0005126891,0.000004453163],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914453,0.003388919,0.003026674,0.0001430707,0.00003562914,0.00002976458,0.0002956704,0.00005992917,0.001575143],"genre_scores_gemma":[0.9962624,0.001020184,0.0005254052,0.00002504372,0.000005889346,0.00001685019,0.0001549455,0.000004411854,0.001984835],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001297404,"threshold_uncertainty_score":0.004340291,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00791192448493306,"score_gpt":0.2424659996239139,"score_spread":0.2345540751389809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}