{"id":"W2043293085","doi":"10.1097/qai.0b013e3181fe9450","title":"Reduced Replication Capacity of NL4-3 Recombinant Viruses Encoding Reverse Transcriptase–Integrase Sequences From HIV-1 Elite Controllers","year":2010,"lang":"en","type":"article","venue":"JAIDS Journal of Acquired Immune Deficiency Syndromes","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"AIDS Vancouver; Simon Fraser University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Simon Fraser University; Howard Hughes Medical Institute","keywords":"Reverse transcriptase; Integrase; Virology; Recombinant DNA; Human immunodeficiency virus (HIV); Lentivirus; Biology; Replication (statistics); Viral replication; Integrase inhibitor; Virus; Genetics; Gene; Viral disease; Polymerase chain reaction; Viral load; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001694752,0.000292351,0.0008738262,0.0005050336,0.0002750113,0.00003755599,0.0006769323,0.0002599619,0.0005376654],"category_scores_gemma":[0.00135042,0.0002152978,0.0004857099,0.0004495857,0.000694974,0.0004477485,0.0000438242,0.0004420312,0.0002338748],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009343854,"about_ca_system_score_gemma":0.0002778789,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000865174,"about_ca_topic_score_gemma":0.0000194803,"domain_scores_codex":[0.9970946,0.0004334669,0.001339073,0.0003922591,0.0002152484,0.0005252933],"domain_scores_gemma":[0.997254,0.0005259059,0.0009727142,0.0007382219,0.0004218799,0.00008725855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000554863,0.0004256722,0.002327942,0.00002250523,0.0004781156,0.00005955012,0.001044779,0.000005078983,0.9890484,0.0002016013,0.0008384112,0.004993093],"study_design_scores_gemma":[0.006885132,0.001763948,0.03197519,0.0004699347,0.0004604814,0.001193538,0.002421543,0.00001488407,0.9479057,0.001035016,0.005441607,0.0004330782],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911448,0.005393768,0.0001206716,0.0005193054,0.001839472,0.0003060078,0.0003463013,0.000038486,0.0002911678],"genre_scores_gemma":[0.9975387,0.001095849,0.0007986817,0.00002860827,0.00002314064,0.00001620822,0.00009335826,0.00002322337,0.0003822608],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04114274,"threshold_uncertainty_score":0.8779589,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03267850239874107,"score_gpt":0.2795990136909141,"score_spread":0.246920511292173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}