{"id":"W2043293085","doi":"10.1097/qai.0b013e3181fe9450","title":"Reduced Replication Capacity of NL4-3 Recombinant Viruses Encoding Reverse Transcriptase–Integrase Sequences From HIV-1 Elite Controllers","year":2010,"lang":"en","type":"article","venue":"JAIDS Journal of Acquired Immune Deficiency Syndromes","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"AIDS Vancouver; Simon Fraser University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Simon Fraser University; Howard Hughes Medical Institute","keywords":"Reverse transcriptase; Integrase; Virology; Recombinant DNA; Human immunodeficiency virus (HIV); Lentivirus; Biology; Replication (statistics); Viral replication; Integrase inhibitor; Virus; Genetics; Gene; Viral disease; Polymerase chain reaction; Viral load; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002712462,0.0003134544,0.0001806532,0.0002778232,0.0001564944,0.000392781,0.0001824873,0.0002232424,0.001445632],"category_scores_gemma":[0.0005209292,0.00008539975,0.0001464972,0.0001220395,0.0001868631,0.0002525409,0.0002076292,0.0004804108,0.0002216337],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002749987,"about_ca_system_score_gemma":0.000112699,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004393296,"about_ca_topic_score_gemma":0.0002640988,"domain_scores_codex":[0.9998295,0.00002048282,0.00001939744,0.00004509804,0.00005184722,0.00003352882],"domain_scores_gemma":[0.9995499,0.0001570756,0.0001149664,0.0000587485,0.00005013519,0.00006909793],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000168732,0.000029445,0.00472837,0.00001719405,0.00001166509,0.00004258421,0.00005466269,0.00009497225,0.9930425,0.00004368397,0.00002211559,0.001744083],"study_design_scores_gemma":[0.00007768994,0.002843849,0.1198601,0.00002074455,0.00007858489,0.001882626,0.0002231653,0.004274304,0.8687828,0.0002035893,0.00173256,0.00002001316],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991758,0.00009543643,0.0004572762,0.000003970943,0.000001415457,0.000005320113,0.00007345451,0.000007916543,0.0001792542],"genre_scores_gemma":[0.9984464,0.00005961017,0.0005042232,0.000009327489,0.000002845239,0.00001125503,0.0005313865,0.00001043379,0.0004245892],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001445632,"threshold_uncertainty_score":0.004836082,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03267850239874107,"score_gpt":0.2795990136909141,"score_spread":0.246920511292173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}