{"id":"W2043321316","doi":"10.3389/fphar.2012.00176","title":"Ouabain Mimics Low Temperature Rescue of F508del-CFTR in Cystic Fibrosis Epithelial Cells","year":2012,"lang":"en","type":"article","venue":"Frontiers in Pharmacology","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Istituto Pasteur-Fondazione Cenci Bolognetti; McGill University","keywords":"Cystic fibrosis transmembrane conductance regulator; Endoplasmic reticulum; Cystic fibrosis; Ouabain; Chloride channel; Cell biology; Mutant; Chemistry; Biology; Medicine; Internal medicine; Biochemistry; Sodium","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001166326,0.0002130183,0.0004806804,0.000149959,0.0002083176,0.0002823033,0.0002362734,0.0003101779,0.001020511],"category_scores_gemma":[0.0001385436,0.0001112009,0.0002720379,0.0001524042,0.0002279809,0.0002055493,0.0002611891,0.0005844547,0.00040412],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002703273,"about_ca_system_score_gemma":0.0002751112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001251919,"about_ca_topic_score_gemma":0.001546315,"domain_scores_codex":[0.9998114,0.00003757747,0.00002345773,0.00003374229,0.00006187889,0.00003200514],"domain_scores_gemma":[0.9998806,0.00002960273,0.00002787615,0.00002687376,0.00001555167,0.0000195328],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005207826,0.00001087973,0.00004146457,0.00001143644,0.000001124455,0.00002271021,0.00001297032,0.00004909504,0.9994456,0.00004871205,0.00001171048,0.0002922954],"study_design_scores_gemma":[0.000008250966,0.0001562447,0.001122699,0.000003270534,0.000003565036,0.0000700546,0.00003663595,0.0004976971,0.9966724,0.00003387819,0.001392132,0.000003183592],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928457,0.0008875611,0.004015015,0.0001783383,0.00004737005,0.00004573908,0.0005527554,0.0001413759,0.001286223],"genre_scores_gemma":[0.9940161,0.0005849456,0.002377864,0.00004473033,0.000007599563,0.00003699871,0.0004315227,0.00004826922,0.002452004],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001251919,"threshold_uncertainty_score":0.003413975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008778226297906682,"score_gpt":0.3026440360686991,"score_spread":0.2938658097707924,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}