{"id":"W2043353593","doi":"10.1016/j.cbi.2011.02.012","title":"Differences in glyoxal and methylglyoxal metabolism determine cellular susceptibility to protein carbonylation and cytotoxicity","year":2011,"lang":"en","type":"article","venue":"Chemico-Biological Interactions","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Methylglyoxal; Protein Carbonylation; Chemistry; Hepatocyte; Biochemistry; Catalase; Lactoylglutathione lyase; Glutathione; Aldehyde dehydrogenase; Bovine serum albumin; Glycation; Antioxidant; Enzyme; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001837317,0.0002307631,0.0002123189,0.0003396824,0.0001646793,0.0003016329,0.0001573341,0.0003581578,0.001580057],"category_scores_gemma":[0.0003090768,0.0002415336,0.0002512534,0.0002378239,0.0003599179,0.0004461084,0.0002199689,0.0004263466,0.0003119269],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002248709,"about_ca_system_score_gemma":0.000105038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005003366,"about_ca_topic_score_gemma":0.000612329,"domain_scores_codex":[0.9998134,0.00004992993,0.00001623308,0.00003738196,0.00002614923,0.00005704342],"domain_scores_gemma":[0.9997194,0.00006791781,0.00006226548,0.00003594698,0.00003201682,0.0000824286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001469049,0.00003948623,0.002728436,0.0000106378,0.00001409909,0.00005200613,0.00003016703,0.0000311012,0.9949367,0.00009637803,0.00001295895,0.0005788746],"study_design_scores_gemma":[0.00002557954,0.001062217,0.09624843,0.000003033895,0.00004401027,0.0005294973,0.0001794076,0.0006241213,0.9005392,0.0002111804,0.0005236345,0.000009764696],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988176,0.0002541758,0.0004556973,0.00002913313,0.000008321807,0.000006300024,0.0001022389,0.000008748477,0.0003177124],"genre_scores_gemma":[0.9987834,0.0001250681,0.0002157689,0.00001772222,0.000004218884,0.000007770579,0.0001477548,0.000005017781,0.0006932616],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001580057,"threshold_uncertainty_score":0.0052858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06923359143264672,"score_gpt":0.312638620670956,"score_spread":0.2434050292383093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}