{"id":"W2043353593","doi":"10.1016/j.cbi.2011.02.012","title":"Differences in glyoxal and methylglyoxal metabolism determine cellular susceptibility to protein carbonylation and cytotoxicity","year":2011,"lang":"en","type":"article","venue":"Chemico-Biological Interactions","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Methylglyoxal; Protein Carbonylation; Chemistry; Hepatocyte; Biochemistry; Catalase; Lactoylglutathione lyase; Glutathione; Aldehyde dehydrogenase; Bovine serum albumin; Glycation; Antioxidant; Enzyme; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001951794,0.0001499818,0.0001812676,0.00006330854,0.00006284776,0.00001622137,0.0001169586,0.000124724,0.00008064287],"category_scores_gemma":[0.0006194817,0.0001213995,0.00003129575,0.0001199222,0.0001684393,0.00001513268,0.0001988436,0.0002055495,0.000003882597],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002251056,"about_ca_system_score_gemma":0.0000168376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000781512,"about_ca_topic_score_gemma":0.0001041456,"domain_scores_codex":[0.9988551,0.0001017119,0.0002265713,0.0005293429,0.00006752352,0.0002197665],"domain_scores_gemma":[0.9994677,0.00003709584,0.00005424333,0.0002321362,0.00008157454,0.0001272797],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001429815,0.00008003836,0.01179266,0.000008328803,0.00001038193,0.00000132185,0.0001425017,4.973685e-7,0.986402,0.00007884802,0.000007958357,0.001332509],"study_design_scores_gemma":[0.000199574,0.0001529585,0.06538611,0.000008537555,0.000004423842,0.000008032634,0.0001145658,0.00003907842,0.9325237,0.0006000992,0.000809507,0.0001534651],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975868,0.0002191131,0.001097397,0.0001245746,0.00004539008,0.0004003165,0.00001608702,0.00001524991,0.0004950005],"genre_scores_gemma":[0.9962422,0.00006079765,0.003146508,0.00006041953,0.00009171533,0.0001115124,0.00003930445,0.000007932912,0.0002396653],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05387833,"threshold_uncertainty_score":0.4950529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06923359143264672,"score_gpt":0.312638620670956,"score_spread":0.2434050292383093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}