{"id":"W2043363289","doi":"10.1002/jps.22472","title":"Investigation on the Possibility of Biowaivers for Ibuprofen","year":2011,"lang":"en","type":"article","venue":"Journal of Pharmaceutical Sciences","topic":"Drug Solubulity and Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":73,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Canada","funders":"Health Canada; Bundesinstitut für Arzneimittel und Medizinprodukte","keywords":"Bioequivalence; Biopharmaceutics Classification System; Ibuprofen; Solubility; Absorption (acoustics); Dissolution; Biopharmaceutics; Chemistry; Chromatography; Pharmacokinetics; Pharmacology; IVIVC; Dissolution testing; Mathematics; In vitro; Materials science; Medicine; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002367684,0.0002571337,0.000145195,0.0002724043,0.0003938774,0.0005483415,0.0002406479,0.0005487637,0.002677953],"category_scores_gemma":[0.0003279024,0.0001547554,0.0002471775,0.0001166383,0.0002507226,0.0005893849,0.0002773989,0.0003294,0.0005195076],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001551711,"about_ca_system_score_gemma":0.0002135703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002827912,"about_ca_topic_score_gemma":0.0003165576,"domain_scores_codex":[0.9998832,0.00002684341,0.000006567629,0.00002175297,0.00003146982,0.00003019608],"domain_scores_gemma":[0.999868,0.0000573518,0.00002196594,0.00001326212,0.00002774764,0.00001165341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003804405,0.00006288163,0.0005200384,0.00009732344,0.00000991783,0.0002158501,0.00005262021,0.0002395375,0.9857582,0.001744147,0.0000795801,0.01083965],"study_design_scores_gemma":[0.000005977823,0.0003315443,0.0005433089,0.000006811228,0.00001498996,0.0001451141,0.00005020123,0.0007677833,0.995173,0.0001612634,0.002796006,0.000004065673],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9818973,0.003639963,0.005236275,0.0002169593,0.00003529147,0.00006277666,0.00006390825,0.00003495207,0.008812458],"genre_scores_gemma":[0.9895913,0.001550275,0.0029718,0.00005712618,0.000009950225,0.00002266339,0.00006029931,0.000009700949,0.005726946],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002677953,"threshold_uncertainty_score":0.008958638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.6089687495431421,"score_gpt":0.492391316547742,"score_spread":0.1165774329954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}