{"id":"W2043366401","doi":"10.1371/journal.pmed.1001796","title":"CD47 Agonist Peptides Induce Programmed Cell Death in Refractory Chronic Lymphocytic Leukemia B Cells via PLCγ1 Activation: Evidence from Mice and Humans","year":2015,"lang":"en","type":"article","venue":"PLoS Medicine","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Inserm Transfert; Fondation de France; Fondation ARC pour la Recherche sur le Cancer; National Cancer Institute; Institut National Du Cancer; Consejo Nacional de Ciencia y Tecnología; Ministerio de Economía y Competitividad; Ligue Contre le Cancer; École Polytechnique Fédérale de Lausanne; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche","keywords":"Chronic lymphocytic leukemia; Cancer research; Immunology; Leukemia; Immune system; Medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003630837,0.0002514246,0.0004516303,0.0001461415,0.0001142506,0.00001642674,0.0002143922,0.0002752361,0.0001223872],"category_scores_gemma":[0.0002060603,0.0002072519,0.00003214013,0.0001868291,0.0002978128,0.0003133432,0.00008230573,0.0003479073,0.0001056063],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002466022,"about_ca_system_score_gemma":0.0007982654,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004004394,"about_ca_topic_score_gemma":0.0001719854,"domain_scores_codex":[0.9984081,0.0002279382,0.0004600669,0.0004318994,0.0001126145,0.0003593725],"domain_scores_gemma":[0.9988832,0.0003583085,0.0002442707,0.0003399144,0.0001061221,0.00006811351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001765156,0.00006877009,0.002117041,0.00005927124,0.0000562497,0.000005614159,0.0023772,0.00002092235,0.991017,0.000007176564,0.0009755575,0.003118628],"study_design_scores_gemma":[0.006331647,0.001066294,0.03646062,0.001410921,0.0001571924,0.00001474298,0.0006867628,0.0005177339,0.9470751,0.0001765142,0.005744875,0.0003575564],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9794335,0.01903459,0.00008746786,0.0002599353,0.0003353734,0.0004318466,0.000003878753,0.00006582079,0.0003475945],"genre_scores_gemma":[0.997883,0.000699812,0.00008979665,0.000144332,0.0002040923,0.0000505063,0.0001579463,0.00002466935,0.0007458277],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04394191,"threshold_uncertainty_score":0.8451486,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05529508250451231,"score_gpt":0.2701051123716319,"score_spread":0.2148100298671196,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}