{"id":"W2043366401","doi":"10.1371/journal.pmed.1001796","title":"CD47 Agonist Peptides Induce Programmed Cell Death in Refractory Chronic Lymphocytic Leukemia B Cells via PLCγ1 Activation: Evidence from Mice and Humans","year":2015,"lang":"en","type":"article","venue":"PLoS Medicine","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Inserm Transfert; Fondation de France; Fondation ARC pour la Recherche sur le Cancer; National Cancer Institute; Institut National Du Cancer; Consejo Nacional de Ciencia y Tecnología; Ministerio de Economía y Competitividad; Ligue Contre le Cancer; École Polytechnique Fédérale de Lausanne; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche","keywords":"Chronic lymphocytic leukemia; Cancer research; Immunology; Leukemia; Immune system; Medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005154673,0.0004979278,0.0002662988,0.0006661688,0.0001925755,0.0003474786,0.0002149545,0.0005351306,0.001534385],"category_scores_gemma":[0.0002246799,0.0002460339,0.0003301571,0.0001655607,0.0005261019,0.0002882391,0.0002112481,0.0005646623,0.0003686666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002696735,"about_ca_system_score_gemma":0.0001420675,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002746994,"about_ca_topic_score_gemma":0.0001827344,"domain_scores_codex":[0.9998201,0.00005708266,0.00001332558,0.0000340302,0.00003493914,0.00004062051],"domain_scores_gemma":[0.9998661,0.00003896964,0.00003766528,0.00002335218,0.000007936335,0.00002587485],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001849651,0.0004329009,0.001741836,0.000114645,0.00004089581,0.0001881905,0.00007124795,0.00009496788,0.9897991,0.000235556,0.0001951958,0.005235764],"study_design_scores_gemma":[0.001585837,0.0156138,0.03221418,0.00009455889,0.0002617306,0.00451259,0.0001675057,0.001306256,0.931462,0.0006671844,0.01208544,0.00002894022],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928033,0.00410105,0.001312195,0.0001787269,0.00001528976,0.00006223655,0.0002956552,0.00007209369,0.00115944],"genre_scores_gemma":[0.9942502,0.003391079,0.0006822261,0.0001761146,0.00002164491,0.00009760074,0.0005556408,0.0000151459,0.0008103896],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001534385,"threshold_uncertainty_score":0.005132973,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05529508250451231,"score_gpt":0.2701051123716319,"score_spread":0.2148100298671196,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}