{"id":"W2043374442","doi":"10.1038/onc.2012.4","title":"The ShcA SH2 domain engages a 14-3-3/PI3′K signaling complex and promotes breast cancer cell survival","year":2012,"lang":"en","type":"article","venue":"Oncogene","topic":"14-3-3 protein interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill University Health Centre; Occupational Cancer Research Centre; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto; Jewish General Hospital","funders":"Canadian Institutes of Health Research; Canadian Breast Cancer Research Alliance; McGill University","keywords":"SH2 domain; Phosphotyrosine-binding domain; Biology; Proto-oncogene tyrosine-protein kinase Src; Cancer research; Receptor tyrosine kinase; GRB2; Carcinogenesis; Cell biology; Signal transduction; Tyrosine kinase; Signal transducing adaptor protein; Tyrosine; Cancer; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003780143,0.0001601083,0.0001191847,0.00001264796,0.0003593759,0.00005073145,0.0001581695,0.00009667173,0.0001843311],"category_scores_gemma":[0.00003322944,0.0001210155,0.00006375893,0.00004742178,0.0001013038,0.000009572908,0.0001390797,0.0001240067,0.00001282056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003218358,"about_ca_system_score_gemma":0.00005160485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002055814,"about_ca_topic_score_gemma":0.0003192659,"domain_scores_codex":[0.9989695,0.0001629017,0.0001621207,0.0002298878,0.0001233936,0.0003522108],"domain_scores_gemma":[0.9993852,0.00005837957,0.00008402194,0.000270649,0.00008174973,0.0001200186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004707466,0.00006609343,0.002655382,0.00001259556,0.00005790948,8.211923e-7,0.0001558254,0.000004049404,0.9919161,0.00004191278,0.0009542894,0.004087927],"study_design_scores_gemma":[0.0004596993,0.00009507064,0.004448059,0.00001925761,0.00003666147,0.00007036953,0.0005762803,0.0000172318,0.8843702,0.00005238557,0.1095869,0.0002678188],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891416,0.006069674,0.0004117634,0.0006883811,0.0003706228,0.0002971605,0.0001306575,0.00001902766,0.002871139],"genre_scores_gemma":[0.9964643,0.0004912594,0.001076802,0.0001149168,0.0008565334,0.0001003042,0.00003924252,0.00003111847,0.000825569],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1086327,"threshold_uncertainty_score":0.4934869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02023577492502774,"score_gpt":0.2845409791607117,"score_spread":0.2643052042356839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}