{"id":"W2043408047","doi":"10.1073/pnas.1010460107","title":"RD3, the protein associated with Leber congenital amaurosis type 12, is required for guanylate cyclase trafficking in photoreceptor cells","year":2010,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Eye Institute; Canadian Institutes of Health Research; Macula Vision Research Foundation","keywords":"Visual phototransduction; GUCY2D; Cell biology; Biology; Endoplasmic reticulum; Intracellular; Retina; Guanylate cyclase; Guanylate cyclase 2C; Genetics; Receptor; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009888014,0.0006106087,0.0002931019,0.0004449299,0.0003203966,0.0002744227,0.0002414965,0.0006210163,0.001418704],"category_scores_gemma":[0.0002298641,0.0002057828,0.0005357226,0.000254599,0.0003343063,0.0001544234,0.0003222064,0.0004318499,0.000603613],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005620857,"about_ca_system_score_gemma":0.0002812395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001462515,"about_ca_topic_score_gemma":0.001684987,"domain_scores_codex":[0.999874,0.00001307523,0.0000170596,0.00003769554,0.0000380926,0.00002002759],"domain_scores_gemma":[0.9997953,0.0000208335,0.0001015902,0.00001454884,0.00001469514,0.00005322028],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007497663,0.000005270264,0.001158613,0.00003046205,0.000008396989,0.0007508243,0.00002325203,0.00003300909,0.9968274,0.00007547069,0.00006357943,0.0009486101],"study_design_scores_gemma":[0.00008500386,0.0002262977,0.1552749,0.000037536,0.0001189475,0.02356716,0.0001389907,0.002830841,0.8076392,0.0003995609,0.009646564,0.00003497849],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907508,0.002190237,0.004776143,0.0001800145,0.00004228602,0.00002121146,0.0007736506,0.0003904562,0.0008751474],"genre_scores_gemma":[0.9940922,0.0005841706,0.002556572,0.00006185751,0.0000115457,0.00002446782,0.0009230835,0.00004855233,0.001697538],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001462515,"threshold_uncertainty_score":0.004746079,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02162632249482384,"score_gpt":0.2662156944529088,"score_spread":0.244589371958085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}