{"id":"W2043408047","doi":"10.1073/pnas.1010460107","title":"RD3, the protein associated with Leber congenital amaurosis type 12, is required for guanylate cyclase trafficking in photoreceptor cells","year":2010,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Eye Institute; Canadian Institutes of Health Research; Macula Vision Research Foundation","keywords":"Visual phototransduction; GUCY2D; Cell biology; Biology; Endoplasmic reticulum; Intracellular; Retina; Guanylate cyclase; Guanylate cyclase 2C; Genetics; Receptor; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006734491,0.00007925952,0.00008103993,0.00004335561,0.0001193197,0.00002146533,0.0003948281,0.00008352454,0.000007975707],"category_scores_gemma":[0.0003995706,0.00004498174,0.00004381572,0.0002638233,0.0004622058,0.00002010187,0.0000513459,0.00009652295,3.304301e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007390044,"about_ca_system_score_gemma":0.00005673272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003738837,"about_ca_topic_score_gemma":0.000003213936,"domain_scores_codex":[0.999147,0.000004358431,0.0001724179,0.0001852482,0.0003580967,0.0001328813],"domain_scores_gemma":[0.9995254,0.00002859386,0.000217237,0.000008390651,0.0002028106,0.00001760306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007582298,0.00002921508,0.004501485,0.000009170988,0.00001553264,2.031392e-9,0.0001180162,0.000008673519,0.9941673,0.0002831624,0.0006985959,0.00009298717],"study_design_scores_gemma":[0.0003275224,0.00009632821,0.0149462,0.0000283604,0.000007342073,7.344853e-7,0.0001292416,0.0002285536,0.9825189,0.0008654051,0.0007701733,0.00008126025],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997491,0.00002890157,4.436896e-7,0.0009326186,0.00002196009,0.0003601476,0.00001175498,0.000002762661,0.001150413],"genre_scores_gemma":[0.9988534,0.000007252078,0.0004916668,0.000211968,0.00002827622,0.00002801405,0.000001037915,0.000004835069,0.000373567],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01164846,"threshold_uncertainty_score":0.1834302,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02162632249482384,"score_gpt":0.2662156944529088,"score_spread":0.244589371958085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}