{"id":"W2043425918","doi":"10.1074/jbc.m000723200","title":"Peptide Mimics of the M13 Coat Protein Transmembrane Segment","year":2000,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University of Toronto; Hospital for Sick Children","funders":"Medical Research Council; Medical Research Council Canada; Hospital for Sick Children; Yale University","keywords":"Helix (gastropod); Peptide; Transmembrane domain; Transmembrane protein; Biophysics; Membrane protein; Chemistry; Protein folding; Crystallography; Structural motif; Peptide sequence; Circular dichroism; Molecular dynamics; Mutant; Protein structure; Biology; Amino acid; Membrane; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000171823,0.0001389143,0.0002185533,0.000006065719,0.00004046454,0.000007647166,0.000397543,0.000252094,0.0002044533],"category_scores_gemma":[0.00006144381,0.00007762561,0.0002735696,0.00006330076,0.0001772097,0.000002606914,0.0000419158,0.0002266024,9.072675e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001412946,"about_ca_system_score_gemma":0.00007255418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001416701,"about_ca_topic_score_gemma":5.989071e-7,"domain_scores_codex":[0.9990926,0.00004221945,0.0003990373,0.0001422169,0.0001601687,0.0001637314],"domain_scores_gemma":[0.9993563,0.000009536891,0.0002395844,0.0002321321,0.00008842369,0.00007405079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000237726,0.00006162703,0.0003597549,0.00003347927,0.00004247242,0.000004536412,0.00001030132,0.00008049064,0.9969519,0.00000447612,0.000164381,0.002048847],"study_design_scores_gemma":[0.0004725242,0.0002114375,0.0006624217,0.00004090239,0.00001699611,0.0001583908,0.00002143869,0.00001006478,0.9869446,0.0002434587,0.01111344,0.0001043964],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971424,0.000599855,0.0001756681,0.0002385966,0.00003601186,0.0001082159,0.000024186,0.000002704813,0.001672412],"genre_scores_gemma":[0.9976299,0.0002664911,0.0008516386,0.0001524962,0.0002374792,0.000003042696,0.0000118845,0.000007425475,0.0008396073],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01094906,"threshold_uncertainty_score":0.316548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007744783515296678,"score_gpt":0.2168168467213538,"score_spread":0.2090720632060571,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}