{"id":"W2043425918","doi":"10.1074/jbc.m000723200","title":"Peptide Mimics of the M13 Coat Protein Transmembrane Segment","year":2000,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University of Toronto; Hospital for Sick Children","funders":"Medical Research Council; Medical Research Council Canada; Hospital for Sick Children; Yale University","keywords":"Helix (gastropod); Peptide; Transmembrane domain; Transmembrane protein; Biophysics; Membrane protein; Chemistry; Protein folding; Crystallography; Structural motif; Peptide sequence; Circular dichroism; Molecular dynamics; Mutant; Protein structure; Biology; Amino acid; Membrane; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001232856,0.0002338242,0.0002078718,0.00007225317,0.0001399855,0.0001925557,0.0002254834,0.0003537922,0.0006246516],"category_scores_gemma":[0.0002426471,0.000117518,0.0001999441,0.0001651719,0.0001347793,0.00009652581,0.000124722,0.0004287276,0.0001814804],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000291885,"about_ca_system_score_gemma":0.0001671941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005249089,"about_ca_topic_score_gemma":0.0005990189,"domain_scores_codex":[0.9998659,0.00002958852,0.00001107977,0.00002388572,0.00004752177,0.0000219585],"domain_scores_gemma":[0.9998683,0.00002461989,0.00003859477,0.00001345701,0.00002064171,0.00003435408],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001437756,0.00004321041,0.0002165347,0.00003425189,0.000007799448,0.00008915489,0.00001540415,0.001687685,0.9969367,0.0002166742,0.00003010839,0.0005786857],"study_design_scores_gemma":[0.00003876712,0.0005929362,0.001957644,0.000004949001,0.0000203432,0.0001694125,0.00002878138,0.009149918,0.9864466,0.00006424409,0.001517527,0.000008804242],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997233,0.0001019259,0.002076166,0.00001968027,0.000009047144,0.00002170709,0.000109245,0.0000204499,0.0004088063],"genre_scores_gemma":[0.9933196,0.0001224522,0.005523433,0.00002604687,0.000002136419,0.00002707353,0.0003260767,0.00001713073,0.0006361674],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006246516,"threshold_uncertainty_score":0.002117753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007744783515296678,"score_gpt":0.2168168467213538,"score_spread":0.2090720632060571,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}