{"id":"W2043463674","doi":"10.1016/j.bmc.2011.02.053","title":"Geminal dialkyl derivatives of N-substituted pantothenamides: Synthesis and antibacterial activity","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Neurological diseases and metabolism","field":"Neuroscience","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; McMaster University","keywords":"Chemistry; Moiety; Substituent; Stereochemistry; Antibacterial activity; Pantothenic acid; Geminal; Mode of action; Chemical synthesis; Total synthesis; Cofactor; Biosynthesis; Structure–activity relationship; Combinatorial chemistry; Bacteria; Biochemistry; In vitro; Riboflavin; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009300881,0.0002243197,0.0001855314,0.0001352841,0.0001402444,0.0001307638,0.0003493763,0.0002289083,0.001455237],"category_scores_gemma":[0.0001167193,0.00007846662,0.0001252515,0.0002170139,0.0001882794,0.0002500189,0.0002255632,0.000364108,0.0003645346],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003963031,"about_ca_system_score_gemma":0.0003049315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009550824,"about_ca_topic_score_gemma":0.002016188,"domain_scores_codex":[0.9999448,0.00000881534,0.000005105729,0.000008374262,0.000008771901,0.0000241051],"domain_scores_gemma":[0.9999547,0.000005057082,0.000008797389,0.000007358734,0.000007355563,0.00001672747],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006168852,0.00004562287,0.0001762674,0.0001683777,0.00001016434,0.0002607929,0.00007301577,0.0005129615,0.9855284,0.001185599,0.0003151562,0.01110676],"study_design_scores_gemma":[0.00005753426,0.001005752,0.001606644,0.000008765238,0.00002264318,0.0003431662,0.00004081755,0.0007432887,0.9868525,0.0002600463,0.009044296,0.00001462724],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9797016,0.004168881,0.005520726,0.0002709214,0.0001025786,0.00006170837,0.0007172186,0.0001641092,0.009292233],"genre_scores_gemma":[0.9925442,0.001777401,0.002171475,0.00004858716,0.00001169727,0.00001873577,0.0002907417,0.00001930488,0.003117811],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001455237,"threshold_uncertainty_score":0.004868269,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05181712339718919,"score_gpt":0.2433765162497901,"score_spread":0.1915593928526009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}