{"id":"W2043463674","doi":"10.1016/j.bmc.2011.02.053","title":"Geminal dialkyl derivatives of N-substituted pantothenamides: Synthesis and antibacterial activity","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Neurological diseases and metabolism","field":"Neuroscience","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; McMaster University","keywords":"Chemistry; Moiety; Substituent; Stereochemistry; Antibacterial activity; Pantothenic acid; Geminal; Mode of action; Chemical synthesis; Total synthesis; Cofactor; Biosynthesis; Structure–activity relationship; Combinatorial chemistry; Bacteria; Biochemistry; In vitro; Riboflavin; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001094934,0.0001941863,0.000326088,0.0000231236,0.00007291001,0.000009743401,0.0002478454,0.0001407176,0.0008234374],"category_scores_gemma":[0.001730861,0.0001490292,0.00006231639,0.000160572,0.0006348413,0.00009904675,0.0001057224,0.0001959373,0.000005406498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009617126,"about_ca_system_score_gemma":0.00006241546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002567283,"about_ca_topic_score_gemma":2.634754e-7,"domain_scores_codex":[0.9987794,0.00006783089,0.0002188263,0.0004262612,0.0002439875,0.0002636706],"domain_scores_gemma":[0.9991125,0.000240533,0.0001701155,0.0002430998,0.00002712467,0.0002065746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003104278,0.0001697901,0.0009641009,0.0001042263,0.000008101129,0.00004927101,0.0001481049,6.255644e-9,0.994473,0.00008172316,0.00001670312,0.003674512],"study_design_scores_gemma":[0.000315285,0.00004134901,0.07937857,0.00004245245,0.00006470257,0.00004717322,0.0000425168,0.000005245013,0.9195895,0.0001355373,0.0002017908,0.0001358723],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977833,0.0001428909,0.00005151049,0.00007067594,0.0001456214,0.0001066756,0.00004762688,0.00005422353,0.001597485],"genre_scores_gemma":[0.9992769,0.0003033703,0.00005248416,0.0001196697,0.0001868568,0.000008913681,9.466731e-7,0.0000149316,0.00003597745],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07841447,"threshold_uncertainty_score":0.9016061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05181712339718919,"score_gpt":0.2433765162497901,"score_spread":0.1915593928526009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}