{"id":"W2043472746","doi":"10.1073/pnas.0603007103","title":"Different mitochondrial intermembrane space proteins are released during apoptosis in a manner that is coordinately initiated but can vary in duration","year":2006,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":248,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Institutes of Health; Institut Gustave-Roussy","keywords":"Mitochondrial intermembrane space; Intermembrane space; Cytochrome c; Cell biology; Apoptosis-inducing factor; Mitochondrial apoptosis-induced channel; Mitochondrion; Biology; Apoptosis; Adenylate kinase; Inner mitochondrial membrane; Cytosol; Biochemistry; Molecular biology; Caspase; Programmed cell death; Bacterial outer membrane; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001950781,0.00009497727,0.0001179096,0.0001609498,0.0000701919,0.00001727551,0.0002252999,0.0001255749,0.000005100031],"category_scores_gemma":[0.00005409463,0.00006817193,0.00005035857,0.0002866285,0.0001450443,0.00002466224,0.00007757785,0.00009166545,1.246383e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004114714,"about_ca_system_score_gemma":0.00002215439,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001009791,"about_ca_topic_score_gemma":0.00001065837,"domain_scores_codex":[0.9989688,0.00000973946,0.0002616766,0.0002409257,0.0003914278,0.0001274093],"domain_scores_gemma":[0.9995725,0.000008281823,0.00030581,0.00001018846,0.00008715158,0.00001603985],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006866024,0.00006086267,0.007949234,0.00005334643,0.000004525991,1.631062e-8,0.00005007029,0.0001110006,0.9908722,0.0007608652,0.00003918343,0.00003002408],"study_design_scores_gemma":[0.0003929404,0.00003030052,0.2333138,0.0001030889,0.000003604531,0.000002102064,0.0001183494,0.0005610879,0.7633235,0.00207852,0.000008795836,0.00006390671],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978032,0.00004942267,0.000001869121,0.001557233,0.00002293665,0.0002791619,0.00001347356,0.000003262966,0.0002694564],"genre_scores_gemma":[0.9994532,0.00002432499,0.000154951,0.00005338945,0.00007472737,0.00002508231,0.000002712766,0.00000464618,0.0002069329],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2275487,"threshold_uncertainty_score":0.2779971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02362861277288486,"score_gpt":0.252918720398668,"score_spread":0.2292901076257832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}