{"id":"W2043494958","doi":"10.1074/jbc.m313487200","title":"Apolipoprotein A-I Activates Cellular cAMP Signaling through the ABCA1 Transporter","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Victoria Hospital; McGill University Health Centre; Royal Victoria Regional Health Centre","funders":"","keywords":"ABCA1; Forskolin; Chinese hamster ovary cell; Protein kinase A; Phosphorylation; Signal transduction; Biology; Protein kinase C; Kinase; Cell biology; Phosphodiesterase 3; Endocrinology; Biochemistry; Receptor; Transporter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001103291,0.000289865,0.000251787,0.0001856025,0.0001822312,0.0003562426,0.0001175132,0.0002662793,0.001102714],"category_scores_gemma":[0.0001302732,0.0001389097,0.0002530389,0.0001602512,0.0002452855,0.0001808023,0.000173174,0.0003809242,0.0003422673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005504303,"about_ca_system_score_gemma":0.0001679449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001445465,"about_ca_topic_score_gemma":0.001555129,"domain_scores_codex":[0.9998922,0.0000322278,0.000007819534,0.00001770344,0.00002234436,0.00002763734],"domain_scores_gemma":[0.99993,0.00002323934,0.00001677371,0.000006827762,0.000008710084,0.00001442012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001707381,0.00002818724,0.0003227804,0.00005828448,0.00000561951,0.0001890653,0.000027454,0.00004573797,0.9976813,0.0001023993,0.00008233777,0.001286133],"study_design_scores_gemma":[0.0001015955,0.0009305683,0.02706848,0.00002775548,0.00004247701,0.001380046,0.0001571635,0.002365984,0.9617254,0.0003689001,0.005813113,0.00001859279],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989032,0.00673781,0.0009284398,0.0002545414,0.00004990572,0.00003001535,0.0002703431,0.000076271,0.002620729],"genre_scores_gemma":[0.9939388,0.003094678,0.0009945354,0.00008029196,0.00002932218,0.00003231499,0.0003071786,0.000007485629,0.001515404],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001445465,"threshold_uncertainty_score":0.00399369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02746077907075273,"score_gpt":0.2560179226783776,"score_spread":0.2285571436076249,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}