{"id":"W2043494958","doi":"10.1074/jbc.m313487200","title":"Apolipoprotein A-I Activates Cellular cAMP Signaling through the ABCA1 Transporter","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Victoria Hospital; McGill University Health Centre; Royal Victoria Regional Health Centre","funders":"","keywords":"ABCA1; Forskolin; Chinese hamster ovary cell; Protein kinase A; Phosphorylation; Signal transduction; Biology; Protein kinase C; Kinase; Cell biology; Phosphodiesterase 3; Endocrinology; Biochemistry; Receptor; Transporter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002403957,0.0001565718,0.0003802943,0.00001098828,0.00006252032,0.00001634721,0.0001781882,0.0001950934,0.0003026392],"category_scores_gemma":[0.0000836535,0.00007292221,0.0003047755,0.00009191659,0.0001482786,0.00006138211,0.00001614657,0.0006212551,0.000006977064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004240997,"about_ca_system_score_gemma":0.00007246587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009541791,"about_ca_topic_score_gemma":1.181517e-7,"domain_scores_codex":[0.9989432,0.0000196672,0.0004445459,0.000136913,0.0002358854,0.0002198609],"domain_scores_gemma":[0.9993216,0.00004495436,0.000247923,0.0001655377,0.00009172306,0.0001283031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002138934,0.0001500925,0.0005002825,0.00003699414,0.00006505028,0.0001129947,0.0002734103,0.00003127894,0.9979308,0.00001589788,0.00003847458,0.0006308937],"study_design_scores_gemma":[0.001576422,0.0001371038,0.002380389,0.0001380891,0.00008178603,0.0005181996,0.0003196715,5.299605e-7,0.9774677,0.001120849,0.01616268,0.0000965431],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939789,0.001367892,0.0005357491,0.003094752,0.000103468,0.00008790522,0.000003428853,0.00001500225,0.000812906],"genre_scores_gemma":[0.9965011,0.0001445732,0.0006428048,0.0008156715,0.00174161,0.000002620531,0.000005250385,0.000009506619,0.0001368572],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.020463,"threshold_uncertainty_score":0.3313687,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02746077907075273,"score_gpt":0.2560179226783776,"score_spread":0.2285571436076249,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}