{"id":"W2043520974","doi":"10.1016/s1074-7613(01)00177-7","title":"The AIDS Disease of CD4C/HIV Transgenic Mice Shows Impaired Germinal Centers and Autoantibodies and Develops in the Absence of IFN-γ and IL-6","year":2001,"lang":"en","type":"article","venue":"Immunity","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":69,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"National Heart, Lung, and Blood Institute","keywords":"Germinal center; Immunoglobulin class switching; Immunology; Biology; CD40; Antibody; Autoantibody; Immune system; Genetically modified mouse; Isotype; Follicular dendritic cells; Affinity maturation; B cell; Transgene; Virology; T cell; In vitro; Monoclonal antibody; Cytotoxic T cell; Antigen-presenting cell; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002063951,0.0009655852,0.0003432831,0.001333367,0.0003541822,0.0005377536,0.0002393288,0.0006881829,0.00205806],"category_scores_gemma":[0.0001958741,0.0003372092,0.0002179934,0.000334204,0.0006197832,0.0003552494,0.0002271701,0.001356517,0.0007944949],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002406114,"about_ca_system_score_gemma":0.0002207711,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005992231,"about_ca_topic_score_gemma":0.0006691508,"domain_scores_codex":[0.9997734,0.0000344881,0.00001713761,0.0000429459,0.00006849012,0.00006348058],"domain_scores_gemma":[0.9994624,0.00006155793,0.0001614136,0.00005961304,0.00003832648,0.0002166639],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000279619,0.0000766314,0.0006232127,0.00003445652,0.00001007142,0.0003480521,0.00003006351,0.00004657234,0.9960109,0.0003075683,0.0001600211,0.002072818],"study_design_scores_gemma":[0.0001788136,0.0008146041,0.02559188,0.00003873076,0.00007627241,0.007199525,0.00013717,0.001420658,0.9578956,0.0009403191,0.005678031,0.00002843342],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913116,0.001244819,0.001794984,0.000228821,0.00005576536,0.00002717784,0.0007343509,0.0003661172,0.004236353],"genre_scores_gemma":[0.991625,0.0008676579,0.001928378,0.00011213,0.00003146484,0.00003023027,0.0006640087,0.00007572774,0.004665373],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00205806,"threshold_uncertainty_score":0.006884873,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01776948513269532,"score_gpt":0.2685584942733003,"score_spread":0.2507890091406049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}