{"id":"W2043520974","doi":"10.1016/s1074-7613(01)00177-7","title":"The AIDS Disease of CD4C/HIV Transgenic Mice Shows Impaired Germinal Centers and Autoantibodies and Develops in the Absence of IFN-γ and IL-6","year":2001,"lang":"en","type":"article","venue":"Immunity","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":69,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"National Heart, Lung, and Blood Institute","keywords":"Germinal center; Immunoglobulin class switching; Immunology; Biology; CD40; Antibody; Autoantibody; Immune system; Genetically modified mouse; Isotype; Follicular dendritic cells; Affinity maturation; B cell; Transgene; Virology; T cell; In vitro; Monoclonal antibody; Cytotoxic T cell; Antigen-presenting cell; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004036333,0.0000989593,0.0001566058,0.00004542205,0.0002281261,0.00001110585,0.0001528972,0.00004457182,0.00001668982],"category_scores_gemma":[0.00007577923,0.00005619968,0.00002961091,0.00008499296,0.0008535592,0.00005182466,0.00006641581,0.0001733583,0.000002906541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008597865,"about_ca_system_score_gemma":0.00005703539,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005628094,"about_ca_topic_score_gemma":0.0004759374,"domain_scores_codex":[0.999087,0.0003753924,0.0001770939,0.0001079136,0.00003611756,0.0002164229],"domain_scores_gemma":[0.9992845,0.0004236002,0.0000462142,0.0001884199,0.00003144836,0.00002581878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001981269,0.0004321064,0.8367512,0.0001305243,0.0003116303,0.00002939071,0.01012455,5.892641e-7,0.1111945,0.0003704977,0.000163859,0.03850988],"study_design_scores_gemma":[0.001167255,0.0001922787,0.9923943,0.00003711714,0.0000271314,0.00005028419,0.002252603,0.000004007688,0.002552969,0.0001372244,0.001122023,0.00006275688],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896363,0.009590656,0.000007743541,0.0003258635,0.00002481654,0.0002019231,0.0001113629,0.000004878502,0.00009644977],"genre_scores_gemma":[0.9964358,0.003308335,0.00002031323,0.00001736629,0.000002227994,0.00001163855,0.00002377219,0.000003503179,0.0001770024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1556431,"threshold_uncertainty_score":0.3144974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01776948513269532,"score_gpt":0.2685584942733003,"score_spread":0.2507890091406049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}