{"id":"W2043531610","doi":"10.1371/journal.pone.0021065","title":"The p53 Tumor Suppressor Is Stabilized by Inhibitor of Growth 1 (ING1) by Blocking Polyubiquitination","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; GlaxoSmithKline (Canada); University of Calgary","funders":"Alberta Heritage Foundation for Medical Research; Bundesministerium für Bildung und Forschung; Canadian Institutes of Health Research; Leuka","keywords":"Deubiquitinating enzyme; Ubiquitin; Ubiquitin ligase; Biology; DNA damage; Cell biology; Gene knockdown; Mdm2; DNA; Biochemistry; Apoptosis; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008077438,0.0005109663,0.0001943712,0.0001865576,0.000150072,0.0002163787,0.0002241412,0.0001808894,0.001491931],"category_scores_gemma":[0.0000634838,0.0001216443,0.000194308,0.0001242486,0.0001943024,0.0001246834,0.0001541538,0.0004462326,0.0004729414],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003420071,"about_ca_system_score_gemma":0.0001201932,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003032543,"about_ca_topic_score_gemma":0.0005525271,"domain_scores_codex":[0.9999162,0.000008070425,0.000007058213,0.00002252352,0.00002009889,0.00002597742],"domain_scores_gemma":[0.9999546,0.000005841575,0.00001963886,0.000005274333,0.000002891149,0.00001182189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001342423,0.00006576256,0.0002777188,0.00004627847,0.000009165896,0.00006962239,0.000007639639,0.0001031159,0.9964335,0.0001630451,0.0001149839,0.00257505],"study_design_scores_gemma":[0.0000219869,0.0003262564,0.003360258,0.00000499413,0.00001893253,0.0003516735,0.00000757728,0.001044477,0.9897942,0.00005034459,0.005016922,0.000002460405],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915348,0.00289468,0.002564085,0.0001358863,0.00003867266,0.00003026852,0.0003449199,0.0002467241,0.002210014],"genre_scores_gemma":[0.9933366,0.001307664,0.001626636,0.00004144761,0.000008435494,0.00002939692,0.0006649375,0.00001757863,0.002967406],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001491931,"threshold_uncertainty_score":0.004990995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02755162273720051,"score_gpt":0.210010606876836,"score_spread":0.1824589841396355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}