{"id":"W2043534390","doi":"10.1177/1087057114546551","title":"Identification of a Putative Tdp1 Inhibitor (CD00509) by in Vitro and Cell-Based Assays","year":2014,"lang":"en","type":"article","venue":"SLAS DISCOVERY","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; Child and Family Research Institute; University of British Columbia; BC Cancer Agency; Centre for Drug Research and Development","funders":"Canadian Institutes of Health Research","keywords":"Camptothecin; Cancer research; Topoisomerase; Biology; Cell culture; PARP inhibitor; Carcinogenesis; Poly ADP ribose polymerase; Synthetic lethality; Molecular biology; DNA damage; In vitro; Cancer cell; DNA repair; Cancer; DNA; Polymerase; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001683564,0.00008181295,0.00009969457,0.00004049742,0.00001750289,0.000022327,0.00005773197,0.00006812053,0.000001351791],"category_scores_gemma":[0.00001835939,0.00008087271,0.00003239257,0.00006367432,0.00004438287,0.000006004445,0.00002767806,0.00003936244,9.361671e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000106464,"about_ca_system_score_gemma":0.00003882931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002336416,"about_ca_topic_score_gemma":0.000009895123,"domain_scores_codex":[0.9994014,0.00004151579,0.0001719383,0.000203112,0.00007627825,0.0001057782],"domain_scores_gemma":[0.999696,0.00001278547,0.0000966649,0.0001450391,0.00002807484,0.00002142778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001125639,0.00005966333,0.00007998991,0.00002225119,0.000007854713,1.492962e-7,0.00003767125,0.00003001535,0.9982492,0.0002575555,0.0001171027,0.001025951],"study_design_scores_gemma":[0.0006508214,0.0001338909,0.0001359216,0.000005887624,0.000009601426,3.07765e-7,0.00005452663,0.000393628,0.995706,0.0007161018,0.002101406,0.00009186421],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9659523,0.0004160304,0.03299592,0.0000714351,0.0001205025,0.0001183125,0.0000975865,0.000002913664,0.0002250231],"genre_scores_gemma":[0.999054,0.00004643444,0.00009848018,0.0001735056,0.00004252593,0.00001808811,0.0001496507,0.00001201499,0.0004052768],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03310174,"threshold_uncertainty_score":0.3297893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004013226511835482,"score_gpt":0.2233464231468178,"score_spread":0.2193331966349823,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}