{"id":"W2043557765","doi":"10.1038/ncomms3593","title":"Structural determinants of HIV-1 Vif susceptibility and DNA binding in APOBEC3F","year":2013,"lang":"en","type":"article","venue":"Nature Communications","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":80,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Canada Research Chairs","funders":"Basic Energy Sciences; National Center for Research Resources; Canadian Institutes of Health Research; National Institutes of Health; University of Toronto; U.S. Department of Energy","keywords":"Human immunodeficiency virus (HIV); DNA; Computational biology; Genetics; Virology; Chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001263809,0.00007610739,0.0001505893,0.0000963697,0.000135895,0.000008345468,0.0003826367,0.0002109511,0.0002160977],"category_scores_gemma":[0.0001374018,0.00006066476,0.00002815306,0.0001235636,0.0003121961,0.00008520613,0.0002624131,0.0005176882,0.0001906899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003459193,"about_ca_system_score_gemma":0.00003142138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002592614,"about_ca_topic_score_gemma":0.00275628,"domain_scores_codex":[0.9992982,0.0002030631,0.0001771994,0.000124576,0.00002267073,0.000174272],"domain_scores_gemma":[0.9988354,0.0002581983,0.00005303172,0.0007682797,0.00006517771,0.00001993964],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00001438224,0.00009997936,0.9069342,0.00001271949,0.00003318711,5.596746e-7,0.0003982959,1.158698e-7,0.0823689,0.000397824,0.0007126916,0.009027165],"study_design_scores_gemma":[0.0007298575,0.00005231883,0.9846543,0.00002379124,0.000008603884,0.00001250079,0.0002445554,0.00002588282,0.01249049,0.0001782776,0.001506062,0.00007335669],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945266,0.003963486,2.907072e-7,0.000521068,0.00003896774,0.0002807998,0.00009037725,0.00001253229,0.000565842],"genre_scores_gemma":[0.9989924,0.0001679081,0.0003559698,0.00001541937,0.000002129724,0.00003492764,0.0001942627,0.000004535405,0.0002324475],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07772013,"threshold_uncertainty_score":0.2473837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02308381265743193,"score_gpt":0.3185571353927468,"score_spread":0.2954733227353149,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}