{"id":"W2043578993","doi":"10.1021/jm301796k","title":"HCV NS5A Replication Complex Inhibitors. Part 4.1 Optimization for Genotype 1a Replicon Inhibitory Activity","year":2013,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Hepatitis C virus research","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Public Health Agency of Canada","keywords":"NS5A; Replicon; Chemistry; Genotype; Potency; Cytotoxicity; Hepatitis C virus; Virology; Hepacivirus; Stereochemistry; Virus; In vitro; Biochemistry; Biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002709629,0.00062847,0.0005558608,0.0005877057,0.000285592,0.0003169317,0.0002738457,0.0002446908,0.004101349],"category_scores_gemma":[0.0001924039,0.0001966278,0.0004615702,0.0003393634,0.0002123463,0.000218612,0.0002401162,0.0004334195,0.0007793568],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004404156,"about_ca_system_score_gemma":0.0006118384,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001584868,"about_ca_topic_score_gemma":0.004622663,"domain_scores_codex":[0.9998517,0.00003229596,0.00001258911,0.00001966494,0.00003654531,0.00004705143],"domain_scores_gemma":[0.999926,0.00001233514,0.00001418326,0.000007535806,0.00001965056,0.00002035601],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000772341,0.0003387177,0.000660225,0.0002757235,0.00002642105,0.0002537886,0.0000915611,0.00321096,0.96456,0.0005750712,0.0006494253,0.02858568],"study_design_scores_gemma":[0.0002431721,0.005747425,0.004036259,0.00003792304,0.00008160959,0.0004755968,0.0000426268,0.00234131,0.9745079,0.0001658511,0.01228259,0.00003782256],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9689359,0.007886179,0.007398417,0.0002325839,0.00005943531,0.0005187954,0.001977599,0.0003624217,0.01262861],"genre_scores_gemma":[0.9796648,0.004422876,0.00700764,0.0001162131,0.00001570171,0.000144363,0.001344404,0.00004365349,0.007240406],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004101349,"threshold_uncertainty_score":0.01372033,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05231648375337469,"score_gpt":0.3383749350647824,"score_spread":0.2860584513114077,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}