{"id":"W2043582759","doi":"10.1002/stem.1276","title":"Inhibition of T Cell Protein Tyrosine Phosphatase Enhances Interleukin-18-Dependent Hematopoietic Stem Cell Expansion","year":2012,"lang":"en","type":"article","venue":"Stem Cells","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; St. Michael's Hospital; Sunnybrook Hospital; University of Toronto","funders":"Sunnybrook Research Institute; McGill University; Lymphoma Foundation","keywords":"Progenitor cell; Biology; Stem cell; Haematopoiesis; Cell biology; Stem cell factor; Hematopoietic stem cell; Interleukin 3; Cytokine; Bone marrow; Ex vivo; Immunology; Endothelial stem cell; T cell; In vivo; In vitro; Interleukin 21; Biochemistry; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003492518,0.0003408722,0.0003249488,0.00006465979,0.0000747231,0.0000290005,0.0002617842,0.0002052433,0.0001280258],"category_scores_gemma":[0.000004077137,0.0003219027,0.0001420944,0.0001320024,0.0001057906,0.00003126351,0.0002839376,0.0001321289,0.0001343044],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003874729,"about_ca_system_score_gemma":0.00007375656,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003258016,"about_ca_topic_score_gemma":0.000004613853,"domain_scores_codex":[0.9980021,0.0001222428,0.0005473951,0.0004720782,0.000337554,0.0005186883],"domain_scores_gemma":[0.9986031,0.00001708222,0.0003952528,0.0006765963,0.0001122928,0.0001956865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001439701,0.0004005506,0.00007379553,0.0004749428,0.00001371471,0.000005220701,0.000163745,0.00000918972,0.9958622,0.000114895,0.001688565,0.00104921],"study_design_scores_gemma":[0.0008353689,0.0004261696,0.00001410352,0.0001638324,0.00003440693,0.000006908204,0.0003687541,0.000003943913,0.9954554,0.00001894717,0.002324336,0.0003478031],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9579707,0.03812809,0.001571907,0.00001629393,0.0003713215,0.0009632377,0.0003019378,0.00003220017,0.0006442707],"genre_scores_gemma":[0.9963613,0.0002241662,0.0006780428,0.00006772731,0.0001761339,0.0001273898,0.0002215737,0.00005512752,0.002088516],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03839058,"threshold_uncertainty_score":0.9999233,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01089769873532531,"score_gpt":0.227815410292107,"score_spread":0.2169177115567817,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}