{"id":"W2043583138","doi":"10.1073/pnas.0406361102","title":"Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model","year":2004,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":411,"is_retracted":false,"has_abstract":true,"ca_institutions":"Surgical Specialties (Canada)","funders":"National Institute on Aging; National Institutes of Health; University of Pennsylvania","keywords":"Tauopathy; Microtubule; Transgene; Genetically modified mouse; Axoplasmic transport; Tau protein; Cell biology; Paclitaxel; Neuroscience; Microtubule-associated protein; Chemistry; Pharmacology; Neurodegeneration; Biology; Biochemistry; Medicine; Internal medicine; Disease; Chemotherapy; Genetics; Alzheimer's disease; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001864845,0.0004920742,0.0008028383,0.0004507822,0.0003239997,0.0002995064,0.0004806542,0.0005215756,0.001197182],"category_scores_gemma":[0.0001527947,0.0001809194,0.0002659157,0.0001924588,0.0003699878,0.0003556845,0.000153718,0.0008081491,0.0001807477],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004873433,"about_ca_system_score_gemma":0.0004902107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001325686,"about_ca_topic_score_gemma":0.003941749,"domain_scores_codex":[0.999882,0.00001801839,0.00000993744,0.00002154208,0.00003003879,0.00003856991],"domain_scores_gemma":[0.9998847,0.00002166076,0.000033845,0.00001216278,0.00001240047,0.00003513676],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008135706,0.0006117794,0.0002941006,0.00007040832,0.00002158275,0.0002393537,0.00003278503,0.0004137468,0.9918398,0.0005070154,0.0001480016,0.005007846],"study_design_scores_gemma":[0.0004619291,0.007727772,0.00189044,0.00001662472,0.00009275418,0.0004370681,0.00003544717,0.002117274,0.9851896,0.0001978743,0.001822058,0.00001102798],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976126,0.000510656,0.0008095567,0.0001163351,0.00002881245,0.00004513385,0.00007005638,0.00006531019,0.0007416395],"genre_scores_gemma":[0.9956583,0.0008265824,0.001632616,0.00004480256,0.00001789187,0.00007749447,0.0001301446,0.00001805704,0.001594049],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001325686,"threshold_uncertainty_score":0.004005015,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04040905921640248,"score_gpt":0.3132504236290607,"score_spread":0.2728413644126582,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}