{"id":"W2043610924","doi":"10.1007/s13238-010-0067-1","title":"Progranulin promotes neurite outgrowth and neuronal differentiation by regulating GSK-3β","year":2010,"lang":"en","type":"article","venue":"Protein & Cell","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":129,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Royal Victoria Hospital","funders":"National Institutes of Health; James S. McDonnell Foundation","keywords":"Neurite; Biology; GSK-3; Cell biology; Frontotemporal lobar degeneration; Gene knockdown; Neurotrophic factors; GSK3B; Staurosporine; Neuroscience; Phosphorylation; Cancer research; Protein kinase A; Internal medicine; Genetics; Apoptosis; Frontotemporal dementia; Receptor; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006921252,0.0002588738,0.0001381205,0.0002482417,0.0001082231,0.000208448,0.00009003648,0.0001187731,0.0007250413],"category_scores_gemma":[0.00007096775,0.00006855676,0.0002369658,0.0001084789,0.0001523263,0.0001073559,0.000165832,0.0003242225,0.0002334417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002640756,"about_ca_system_score_gemma":0.0001986769,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008513076,"about_ca_topic_score_gemma":0.00173683,"domain_scores_codex":[0.999962,0.000006780015,0.000003388765,0.00000674407,0.000009289232,0.0000119209],"domain_scores_gemma":[0.9999669,0.000004130159,0.00001206506,0.000002530197,0.000003191472,0.00001124755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002253064,0.00002943757,0.0008377068,0.0001271572,0.0000158815,0.0004687181,0.00002238608,0.0002042671,0.9929433,0.0002128154,0.0001396753,0.00477338],"study_design_scores_gemma":[0.00007653755,0.0005195562,0.03982471,0.00004592877,0.00006019298,0.001212687,0.0001149389,0.001832774,0.9491422,0.0005845351,0.006572546,0.00001341021],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867476,0.008210969,0.001303344,0.0002285024,0.00002748972,0.0000157934,0.0002128925,0.00009425906,0.003159032],"genre_scores_gemma":[0.9914336,0.004785511,0.001367645,0.00007257855,0.0000114746,0.00002346758,0.0001944415,0.00000982717,0.002101485],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008513076,"threshold_uncertainty_score":0.002425492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0103934989258111,"score_gpt":0.2444921381887455,"score_spread":0.2340986392629344,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}