{"id":"W2043624735","doi":"10.1016/j.molcel.2014.06.018","title":"A Methylation-Phosphorylation Switch Determines Sox2 Stability and Function in ESC Maintenance or Differentiation","year":2014,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":199,"is_retracted":false,"has_abstract":false,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Science and Technology Commission of Shanghai Municipality; East China Normal University; Ministry of Science and Technology of the People's Republic of China; National Natural Science Foundation of China; Wellcome Trust","keywords":"Biology; SOX2; Phosphorylation; Ubiquitin ligase; Cell biology; Downregulation and upregulation; Embryonic stem cell; Ubiquitin; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003823183,0.0001441356,0.0001314493,0.00006881525,0.0000510895,0.0000343931,0.00009253426,0.0001352572,0.00003133496],"category_scores_gemma":[0.0001445094,0.0001279696,0.00004511837,0.0001305317,0.00004002904,0.000008850614,0.0000893776,0.00009309629,0.000008210135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002797363,"about_ca_system_score_gemma":0.00003439491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004192673,"about_ca_topic_score_gemma":0.0001693454,"domain_scores_codex":[0.9987446,0.0001844292,0.0002216603,0.0004268368,0.0001852168,0.0002372791],"domain_scores_gemma":[0.9994427,0.00002608374,0.00007546826,0.0003027213,0.00008643737,0.00006660323],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000216468,0.00005839543,0.01240229,0.00006102562,0.000007685866,0.000002507795,0.00003018834,0.00009183536,0.9804215,0.00002432029,0.00003174799,0.006652042],"study_design_scores_gemma":[0.001072902,0.0002831024,0.03651898,0.0000139725,0.00001474062,0.000002449062,0.00003086263,0.0125588,0.9465005,0.0003283339,0.002470111,0.0002052567],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9079314,0.0002482363,0.0906195,0.00006957349,0.00006395442,0.0002809484,0.000002977586,0.0000103758,0.0007730495],"genre_scores_gemma":[0.9988371,0.00006855827,0.0004177123,0.00007880753,0.00003339934,0.0000369122,0.00009812466,0.00002076406,0.0004085792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09090576,"threshold_uncertainty_score":0.5218449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01053737613002155,"score_gpt":0.2352492628871312,"score_spread":0.2247118867571097,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}