{"id":"W2043627419","doi":"10.1007/s00427-010-0349-x","title":"Knockdown of SPARC leads to decreased cell–cell adhesion and lens cataracts during post-gastrula development in Xenopus laevis","year":2011,"lang":"en","type":"article","venue":"Development Genes and Evolution","topic":"Bone and Dental Protein Studies","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital; Hospital for Sick Children","funders":"Natural Sciences and Engineering Research Council of Canada; Scheme for Promotion of Academic and Research Collaboration","keywords":"Xenopus; Gastrulation; Cell biology; Embryo; Biology; Morpholino; Embryogenesis; Cell adhesion; Developmental biology; Anatomy; Cell; Gene knockdown; Cell culture; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000235093,0.0004711966,0.0004765177,0.0005803411,0.0004055456,0.0006100508,0.0004309739,0.0004828783,0.003601766],"category_scores_gemma":[0.0001605962,0.0005916429,0.0004858217,0.0002006589,0.0005312169,0.0003850697,0.0003214234,0.0008616581,0.0008458766],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007167718,"about_ca_system_score_gemma":0.0004314071,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004357764,"about_ca_topic_score_gemma":0.008878783,"domain_scores_codex":[0.9997092,0.00003478341,0.00004704517,0.00007347137,0.00006175933,0.0000737611],"domain_scores_gemma":[0.9996215,0.00007043438,0.0001231442,0.00003946239,0.0000300953,0.0001153462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001391245,0.00001482614,0.0001112367,0.0000296277,0.000007774703,0.0000870857,0.00001922108,0.00004705437,0.9990619,0.0001043783,0.00004968273,0.0003281628],"study_design_scores_gemma":[0.00003600212,0.0001089513,0.006814329,0.00000805788,0.00003016478,0.0002275187,0.0000672294,0.0007538956,0.9900072,0.00003329839,0.001905558,0.000007744563],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934306,0.001933342,0.001668056,0.0001788541,0.0000785086,0.00001956102,0.0009731723,0.0001575354,0.001560336],"genre_scores_gemma":[0.9826104,0.0009787986,0.001411026,0.0001336563,0.00001903137,0.00005319988,0.00094134,0.0001467879,0.01370585],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004357764,"threshold_uncertainty_score":0.01204908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02247346975896741,"score_gpt":0.2177675457706568,"score_spread":0.1952940760116894,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}