{"id":"W2043637943","doi":"10.1523/jneurosci.5874-09.2010","title":"Identification of Caspase-6-Mediated Processing of the Valosin Containing Protein (p97) in Alzheimer's Disease: A Novel Link to Dysfunction in Ubiquitin Proteasome System-Mediated Protein Degradation","year":2010,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; McGill University","funders":"National Institute on Aging; Canadian Institutes of Health Research; Genome Canada","keywords":"AAA proteins; Proteasome; Biology; Protein degradation; Ubiquitin; Cell biology; Proteolysis; Caspase; NLRP1; ATPase; Biochemistry; Chemistry; Programmed cell death; Apoptosis; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001587137,0.0003605126,0.0002702291,0.0003334822,0.0001486137,0.0002631608,0.0002530664,0.0004997193,0.000710559],"category_scores_gemma":[0.0001406153,0.0001303619,0.0002722589,0.0001902344,0.0002848912,0.0003399578,0.0002073767,0.0006117501,0.000329116],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001937548,"about_ca_system_score_gemma":0.0001028003,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001066208,"about_ca_topic_score_gemma":0.00007920954,"domain_scores_codex":[0.9999191,0.00001002254,0.00001376947,0.0000184764,0.00002602359,0.00001265976],"domain_scores_gemma":[0.9999028,0.0000120891,0.00003101367,0.00000924247,0.00001773213,0.00002708866],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003862362,0.00006433582,0.001512907,0.0001047691,0.00001395221,0.001128423,0.00003086699,0.00003407426,0.9930907,0.0001355161,0.00004148742,0.0034565],"study_design_scores_gemma":[0.00006450135,0.0006404415,0.03384253,0.00002241854,0.00005529144,0.01937265,0.00007692594,0.000984669,0.9417079,0.0005022903,0.00271766,0.00001251263],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933088,0.003653556,0.002222625,0.0001203966,0.00002415559,0.00001621979,0.0001453272,0.00002502082,0.0004838283],"genre_scores_gemma":[0.9940174,0.002522199,0.002235871,0.00004416468,0.00002345389,0.00001556936,0.0003982381,0.000004774609,0.0007384052],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000710559,"threshold_uncertainty_score":0.002377033,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01341583766648007,"score_gpt":0.2532680497357199,"score_spread":0.2398522120692398,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}