{"id":"W2043644171","doi":"10.1016/j.trsl.2011.07.002","title":"Acyclovir-induced nephrotoxicity: the role of the acyclovir aldehyde metabolite","year":2011,"lang":"en","type":"article","venue":"Translational research","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University; University of Toronto; University of Waterloo; Hospital for Sick Children","funders":"","keywords":"Nephrotoxicity; Aldehyde dehydrogenase; ALDH2; In vitro; Metabolite; Biochemistry; Pharmacology; Enzyme; Chemistry; Aldehyde; Programmed cell death; Kidney; Molecular biology; Biology; Endocrinology; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000374756,0.0004225602,0.0003273661,0.0004314166,0.0002308045,0.000637334,0.0003070149,0.0004584166,0.001763503],"category_scores_gemma":[0.0003228465,0.000107705,0.0002398549,0.0002731872,0.0004613828,0.0008754148,0.0003526794,0.000451948,0.0001445482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004448042,"about_ca_system_score_gemma":0.0004071471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004841905,"about_ca_topic_score_gemma":0.0007359589,"domain_scores_codex":[0.9998217,0.00006703271,0.00001187256,0.00002263378,0.00004129514,0.00003549829],"domain_scores_gemma":[0.9996873,0.0000717833,0.0001012033,0.00002911898,0.00004350212,0.0000671787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.005864811,0.0004409584,0.01434333,0.001550182,0.0002441354,0.005189755,0.0002478945,0.001602707,0.7328751,0.007966512,0.001049556,0.228625],"study_design_scores_gemma":[0.0003560437,0.01040118,0.1063897,0.0004411564,0.0004315111,0.02848813,0.0006258137,0.006146169,0.7719044,0.008382099,0.06629286,0.0001409934],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7033525,0.2750624,0.006012475,0.002391117,0.0004026193,0.0000782033,0.000193156,0.0001076443,0.01239995],"genre_scores_gemma":[0.9671967,0.02930678,0.00121791,0.0001773967,0.0002208363,0.00001082041,0.00005449687,0.000007088531,0.001808],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001763503,"threshold_uncertainty_score":0.005899489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1586413336521252,"score_gpt":0.3835483264492933,"score_spread":0.224906992797168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}