{"id":"W2043678464","doi":"10.1021/bc060159m","title":"Proton-Actuated Membrane-Destabilizing Polyion Complex Micelles","year":2007,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Chemistry; Micelle; Cationic polymerization; Membrane; Copolymer; Endosome; Nuclease; Combinatorial chemistry; Biophysics; Bilayer; Methacrylic acid; Oligonucleotide; Dissociation (chemistry); Polyelectrolyte; Cell; Aqueous solution; Biochemistry; Organic chemistry; Polymer; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000135793,0.00022725,0.00009277292,0.00007732346,0.00007991277,0.0002095144,0.0001108202,0.0002388808,0.0007273943],"category_scores_gemma":[0.0001602994,0.00008853243,0.0001031465,0.00005528025,0.000169951,0.0002066862,0.0001231447,0.000264672,0.0002223975],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001849247,"about_ca_system_score_gemma":0.0001286198,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001849317,"about_ca_topic_score_gemma":0.0002349745,"domain_scores_codex":[0.9999275,0.00001137591,0.00000552113,0.00001722011,0.00001986793,0.00001854549],"domain_scores_gemma":[0.9999282,0.0000170808,0.00002355278,0.000006108145,0.00001043304,0.00001442163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002032163,0.000003302815,0.00002136225,0.00001094317,0.000001319172,0.00001390806,0.000006648478,0.00003150813,0.9993755,0.00005654414,0.00001001946,0.0004486253],"study_design_scores_gemma":[0.000005390566,0.00004216106,0.0001796915,8.17917e-7,0.000001990895,0.00004062167,0.00000236802,0.0002716569,0.9987937,0.00001057307,0.0006496491,0.000001418155],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909961,0.0009872204,0.006123492,0.00007515324,0.00002415863,0.00003882069,0.00005292231,0.00007408088,0.001628095],"genre_scores_gemma":[0.9935308,0.0004805234,0.003848112,0.00005616216,0.000009175516,0.00002499872,0.0000880661,0.00001443203,0.001947876],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007273943,"threshold_uncertainty_score":0.00243336,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02021288499517804,"score_gpt":0.2690597732272376,"score_spread":0.2488468882320595,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}