{"id":"W2043678464","doi":"10.1021/bc060159m","title":"Proton-Actuated Membrane-Destabilizing Polyion Complex Micelles","year":2007,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Chemistry; Micelle; Cationic polymerization; Membrane; Copolymer; Endosome; Nuclease; Combinatorial chemistry; Biophysics; Bilayer; Methacrylic acid; Oligonucleotide; Dissociation (chemistry); Polyelectrolyte; Cell; Aqueous solution; Biochemistry; Organic chemistry; Polymer; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000257412,0.0002658212,0.0001877648,0.00002704863,0.0001101751,0.0000422029,0.0003089648,0.0002673418,0.000264852],"category_scores_gemma":[0.00005080244,0.0002623106,0.0001317372,0.0000993418,0.0001426729,0.000005825037,0.00012867,0.0001282793,0.00005885609],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002824889,"about_ca_system_score_gemma":0.00006837347,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000422641,"about_ca_topic_score_gemma":0.0000109935,"domain_scores_codex":[0.9985207,0.00001715537,0.0003546955,0.0005081852,0.0001489208,0.0004503669],"domain_scores_gemma":[0.9991264,0.00001365365,0.00012281,0.0004574413,0.000116891,0.0001627535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000197741,0.00006338527,0.001879262,0.0001056301,0.00004128364,0.00001134729,0.00003548761,0.000003413027,0.9960097,0.000003060963,0.0008579881,0.0007916987],"study_design_scores_gemma":[0.0004752235,0.00007988147,0.0004666542,0.0000310852,0.00001292989,0.0000399675,0.0002167643,0.00002526293,0.9587891,0.00001378701,0.03952291,0.0003264806],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991074,0.000366176,0.0003449171,0.00008914718,0.0000889793,0.0003254719,0.00002238131,0.00005236179,0.007636591],"genre_scores_gemma":[0.9970129,0.0001488681,0.0003876661,0.0002766544,0.000374043,0.00003154884,0.0003931323,0.0000371667,0.001337995],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03866493,"threshold_uncertainty_score":0.9999829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02021288499517804,"score_gpt":0.2690597732272376,"score_spread":0.2488468882320595,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}