{"id":"W2043688773","doi":"10.1371/journal.pone.0069147","title":"Expression of Human Gaucher Disease Gene GBA Generates Neurodevelopmental Defects and ER Stress in Drosophila Eye","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; University of Tokyo; National Institute of Advanced Industrial Science and Technology","keywords":"Endoplasmic reticulum; Unfolded protein response; Glucocerebrosidase; Phenotype; Biology; Compound eye; Gene; Genetics; Chemical chaperone; Gene expression; Lysosomal storage disease; Mutant; Cell biology; Enzyme; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000918187,0.0003569177,0.0001708335,0.0002794506,0.0001718856,0.0002215068,0.0001489485,0.0002850961,0.0009622189],"category_scores_gemma":[0.00007022319,0.0001419608,0.0002634502,0.0001185914,0.000213115,0.000133106,0.0002631146,0.0003756842,0.0003270541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003429091,"about_ca_system_score_gemma":0.0001636004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001087912,"about_ca_topic_score_gemma":0.00190973,"domain_scores_codex":[0.9999278,0.00001232073,0.00001223485,0.00001793363,0.00001556782,0.00001403378],"domain_scores_gemma":[0.9999334,0.00001345449,0.00001987015,0.000008106834,0.000005372096,0.0000197957],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004338362,0.000008479689,0.0001270269,0.00001692784,0.000003976648,0.00009730391,0.00001013701,0.00002780924,0.9992875,0.00007442607,0.00001761112,0.0002855136],"study_design_scores_gemma":[0.0000310697,0.0001644785,0.007468909,0.00001189157,0.00002655404,0.0008725654,0.00006062164,0.0008735675,0.9879979,0.00009362429,0.002392504,0.000006333103],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964701,0.0006195294,0.00126154,0.00009154714,0.00001669288,0.00002271477,0.0005298264,0.00005645556,0.0009314981],"genre_scores_gemma":[0.9942694,0.000530654,0.002017182,0.00004752881,0.00000394364,0.00002362029,0.0005911202,0.00003464743,0.002481993],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001087912,"threshold_uncertainty_score":0.003218949,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04128027940839676,"score_gpt":0.2740476501423296,"score_spread":0.2327673707339329,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}