{"id":"W2043762754","doi":"10.1523/jneurosci.2939-09.2009","title":"Chronic Nicotine Selectively Enhances α4β2* Nicotinic Acetylcholine Receptors in the Nigrostriatal Dopamine Pathway","year":2009,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":114,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"National Institute on Drug Abuse; National Institute on Aging; National Institute of Mental Health; National Alliance for Research on Schizophrenia and Depression; Tobacco-Related Disease Research Program","keywords":"Methyllycaconitine; Substantia nigra; Pars compacta; Medium spiny neuron; Nicotinic agonist; GABAergic; Neuroscience; Nicotine; Chemistry; Dopaminergic; Glutamate receptor; Acetylcholine; Striatum; Dopamine; Nigrostriatal pathway; Nicotinic acetylcholine receptor; Pharmacology; Biology; Inhibitory postsynaptic potential; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009342089,0.0003021017,0.0003322268,0.000112833,0.000103558,0.0002558324,0.0002399683,0.0002644344,0.0008928108],"category_scores_gemma":[0.00009067287,0.0001490592,0.0002642003,0.00009063812,0.0002013759,0.0002170635,0.0001529686,0.0006292456,0.0002148572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000259182,"about_ca_system_score_gemma":0.000170266,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001885219,"about_ca_topic_score_gemma":0.005244107,"domain_scores_codex":[0.9998871,0.00001086328,0.00001252319,0.00002895636,0.00003026903,0.00003020919],"domain_scores_gemma":[0.9999154,0.00001320284,0.00001863318,0.00001311683,0.00001795976,0.00002168726],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004195825,0.00001498166,0.000119869,0.00001465254,0.000006541747,0.00002434952,0.000009236027,0.000009371603,0.9993394,0.00001722949,0.000005386911,0.0003969871],"study_design_scores_gemma":[0.00001558469,0.001217661,0.0113829,0.00000845694,0.00007079431,0.0003062361,0.00005056252,0.0005052298,0.9852797,0.00003750017,0.001121226,0.00000405816],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958799,0.001072928,0.001689646,0.00003756173,0.00002643564,0.0000245956,0.0001570502,0.00004493201,0.001066893],"genre_scores_gemma":[0.9938331,0.001214068,0.001660644,0.00004940894,0.00001161283,0.00004641434,0.0003987067,0.00001990135,0.0027663],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001885219,"threshold_uncertainty_score":0.003748536,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01362477405362979,"score_gpt":0.2781948885156545,"score_spread":0.2645701144620247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}