{"id":"W2043762754","doi":"10.1523/jneurosci.2939-09.2009","title":"Chronic Nicotine Selectively Enhances α4β2* Nicotinic Acetylcholine Receptors in the Nigrostriatal Dopamine Pathway","year":2009,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":114,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"National Institute on Drug Abuse; National Institute on Aging; National Institute of Mental Health; National Alliance for Research on Schizophrenia and Depression; Tobacco-Related Disease Research Program","keywords":"Methyllycaconitine; Substantia nigra; Pars compacta; Medium spiny neuron; Nicotinic agonist; GABAergic; Neuroscience; Nicotine; Chemistry; Dopaminergic; Glutamate receptor; Acetylcholine; Striatum; Dopamine; Nigrostriatal pathway; Nicotinic acetylcholine receptor; Pharmacology; Biology; Inhibitory postsynaptic potential; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00151836,0.0002652414,0.0003415918,0.0001571026,0.0001396127,0.00007460565,0.001271209,0.0001121842,0.00001010956],"category_scores_gemma":[0.001074756,0.0001811946,0.0001986173,0.0008813355,0.0001910711,0.00004380305,0.0001101311,0.000599122,0.000005434404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006755032,"about_ca_system_score_gemma":0.0004375885,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003280758,"about_ca_topic_score_gemma":0.00003318428,"domain_scores_codex":[0.9973243,0.0003218921,0.000790209,0.000444826,0.0006088773,0.0005099135],"domain_scores_gemma":[0.9985863,0.00007346305,0.0006431389,0.0003913257,0.0001855546,0.0001202305],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008981697,0.0002848437,0.001552238,0.000003828013,0.000005025823,0.000003797453,0.0001032265,0.0001317215,0.9907222,0.00001556209,0.001267937,0.005819796],"study_design_scores_gemma":[0.002300457,0.00654504,0.02135808,0.00006071417,0.00002210463,0.000661038,0.0002034163,0.00008489801,0.9019741,0.00003381166,0.06638818,0.0003681447],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994891,0.001431907,0.0004300806,0.001771948,0.0009384676,0.0002523537,0.000005996964,0.000007828447,0.0002704321],"genre_scores_gemma":[0.9961463,0.001082052,0.0002415713,0.0009664064,0.001239874,0.000003641006,0.000003779072,0.00001562182,0.0003008069],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0887481,"threshold_uncertainty_score":0.7388901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01362477405362979,"score_gpt":0.2781948885156545,"score_spread":0.2645701144620247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}