{"id":"W2043773172","doi":"10.3390/ph7010046","title":"Ritonavir-Mediated Induction of Apoptosis in Pancreatic Cancer Occurs via the RB/E2F-1 and AKT Pathways","year":2014,"lang":"en","type":"article","venue":"Pharmaceuticals","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"","keywords":"Ritonavir; Protein kinase B; Cancer research; Cell growth; Cell cycle; PI3K/AKT/mTOR pathway; E2F; Retinoblastoma protein; Drug repositioning; Gemcitabine; Apoptosis; Pharmacology; Biology; Medicine; Internal medicine; Cancer; Virology; Drug; Viral load; Human immunodeficiency virus (HIV); Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006425314,0.000127119,0.0001698373,0.00005156257,0.00005064866,0.00001163957,0.0001684841,0.0001031847,0.00008312302],"category_scores_gemma":[0.0001307308,0.00009598955,0.00004242082,0.0001693303,0.0002090056,0.000004536752,0.00007866618,0.0001736834,0.000009637239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000169932,"about_ca_system_score_gemma":0.00005006467,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007599517,"about_ca_topic_score_gemma":0.00006345727,"domain_scores_codex":[0.9987717,0.0002989683,0.0002185641,0.0002576283,0.0001796118,0.0002734879],"domain_scores_gemma":[0.9994445,0.00009085767,0.00005835898,0.0002463826,0.00006226904,0.00009763939],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004839671,0.00006319356,0.007399421,0.00003226236,0.00004941714,2.415765e-7,0.00007289784,0.00002504273,0.9698681,0.0000169834,0.0001858037,0.02180265],"study_design_scores_gemma":[0.0009369847,0.0003741425,0.00276237,0.00001810803,0.00002831938,0.000002132616,0.00002835348,0.0008839342,0.9893203,0.0001190083,0.005400172,0.0001261214],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963593,0.002218227,0.00006810865,0.000742682,0.00007873678,0.0002778921,0.00002796015,0.000007778609,0.0002192414],"genre_scores_gemma":[0.9972952,0.001815164,0.00003020929,0.0005484592,0.0001404352,0.00009151792,0.00002652644,0.00001834032,0.00003414887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02167653,"threshold_uncertainty_score":0.391434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04960883884679566,"score_gpt":0.3664284377718657,"score_spread":0.31681959892507,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}