{"id":"W2043773172","doi":"10.3390/ph7010046","title":"Ritonavir-Mediated Induction of Apoptosis in Pancreatic Cancer Occurs via the RB/E2F-1 and AKT Pathways","year":2014,"lang":"en","type":"article","venue":"Pharmaceuticals","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"","keywords":"Ritonavir; Protein kinase B; Cancer research; Cell growth; Cell cycle; PI3K/AKT/mTOR pathway; E2F; Retinoblastoma protein; Drug repositioning; Gemcitabine; Apoptosis; Pharmacology; Biology; Medicine; Internal medicine; Cancer; Virology; Drug; Viral load; Human immunodeficiency virus (HIV); Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001833045,0.0003061914,0.0001813678,0.0003006645,0.0001526992,0.000355793,0.0001215698,0.000194358,0.001377515],"category_scores_gemma":[0.0001377229,0.0001169078,0.0002785773,0.0001766693,0.0001443339,0.0002230067,0.0001509776,0.0003823249,0.000277912],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002251766,"about_ca_system_score_gemma":0.0001768976,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002173646,"about_ca_topic_score_gemma":0.0003559191,"domain_scores_codex":[0.9998277,0.00004876973,0.0000148565,0.00002328883,0.00004594864,0.0000392716],"domain_scores_gemma":[0.999944,0.00001325025,0.00001576968,0.00001108044,0.000009098545,0.000006861593],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004085631,0.0001109108,0.001258247,0.0001149131,0.00002156191,0.0001650898,0.00002573213,0.0001819401,0.9835654,0.0004385427,0.00009181949,0.0136172],"study_design_scores_gemma":[0.00003130704,0.0005230343,0.01467595,0.00001258006,0.00002467571,0.0009303789,0.00002752118,0.000768229,0.9777619,0.000139866,0.005099675,0.00000484025],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9760126,0.01510315,0.00287589,0.0001496283,0.00003883254,0.00004097604,0.0004341874,0.00008462341,0.005260051],"genre_scores_gemma":[0.9902883,0.00506842,0.001858616,0.00005353904,0.00001000149,0.00003278104,0.0005229299,0.000006660515,0.002158728],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001377515,"threshold_uncertainty_score":0.004608274,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04960883884679566,"score_gpt":0.3664284377718657,"score_spread":0.31681959892507,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}