{"id":"W2043801611","doi":"10.1080/00397911.2014.888080","title":"Combining a Click–Multicomponent Reaction: One-Pot Synthesis of 1,2,3-Triazol-4-ylmethyl 3-Amino-5,10-dihydro-5,10-dioxo-1<i>H</i>-pyrazolo[1,2-<i>b</i>]phthalazine-2-carboxylate Derivatives","year":2014,"lang":"en","type":"article","venue":"Synthetic Communications","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of New Brunswick","funders":"","keywords":"Chemistry; Phthalazine; Ethyl cyanoacetate; Benzaldehyde; Ionic liquid; Methylene; Catalysis; Condensation reaction; Medicinal chemistry; Organic chemistry; Condensation; Malononitrile","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0008460414,0.000590506,0.0009611733,0.0001751335,0.0008326874,0.00008394838,0.002531602,0.0003791013,0.001814921],"category_scores_gemma":[0.001949199,0.0006587863,0.000447122,0.0006274814,0.001027231,0.0001922651,0.000931918,0.000750142,0.0003606053],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001750098,"about_ca_system_score_gemma":0.0001216946,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001517773,"about_ca_topic_score_gemma":0.00003076753,"domain_scores_codex":[0.9961993,0.0002995702,0.001486743,0.0008180469,0.0005528578,0.0006434833],"domain_scores_gemma":[0.9871386,0.005205365,0.0009976552,0.005963141,0.0003811725,0.0003140525],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008511557,0.001634351,0.0003525421,0.0002685189,0.0003169572,8.230508e-7,0.0005166908,0.00006675023,0.9778863,0.003950922,0.0003199686,0.01460106],"study_design_scores_gemma":[0.001101303,0.00004489359,0.001134076,0.0007273807,0.0004697241,0.00004111588,0.0007085802,0.004389688,0.8756012,0.00197967,0.1128893,0.0009130375],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7227033,0.0006483832,0.0004337475,0.005182351,0.00009145356,0.0004835855,0.00024212,0.0006158844,0.2695991],"genre_scores_gemma":[0.9907989,0.0004668062,0.004317906,0.00005366389,0.0001290233,0.0007867306,0.0002405939,0.0001085392,0.003097833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2680956,"threshold_uncertainty_score":0.9995863,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04110674999087646,"score_gpt":0.2850928169383439,"score_spread":0.2439860669474674,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}