{"id":"W2043841254","doi":"10.1128/aac.00615-10","title":"Resistance of Herpes Simplex Viruses to Nucleoside Analogues: Mechanisms, Prevalence, and Management","year":2010,"lang":"en","type":"review","venue":"Antimicrobial Agents and Chemotherapy","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":555,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Famciclovir; Penciclovir; Virology; Foscarnet; Biology; Thymidine kinase; Herpes simplex virus; Cidofovir; Nucleoside analogue; Mutant; Virus; Nucleoside; Herpesviridae; Gene; Viral disease; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001471761,0.0004063553,0.0005312719,0.001113047,0.0002468828,0.001133525,0.0007981004,0.0006797208,0.001623039],"category_scores_gemma":[0.003149253,0.0001709557,0.0002560792,0.001035396,0.0003957504,0.0008703952,0.0004386941,0.0007199603,0.0007894314],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000698683,"about_ca_system_score_gemma":0.0005677273,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00105934,"about_ca_topic_score_gemma":0.0004988216,"domain_scores_codex":[0.9990689,0.0002229152,0.0001546708,0.0001460871,0.0003260909,0.000081304],"domain_scores_gemma":[0.9988513,0.0002589666,0.000371372,0.00007652996,0.0003280558,0.0001137063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00050025,0.0002439762,0.1094645,0.001843048,0.00008238569,0.001467083,0.0005678327,0.0004726221,0.01432106,0.002135901,0.005742003,0.8631594],"study_design_scores_gemma":[0.0001292088,0.002939674,0.4115024,0.005019441,0.0006626114,0.1137445,0.00349567,0.004429343,0.04431196,0.007774646,0.4057538,0.0002367212],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2340095,0.7402231,0.007588779,0.004117569,0.0002722411,0.0001903458,0.0006813129,0.0002707388,0.01264645],"genre_scores_gemma":[0.7357513,0.2552084,0.004362816,0.000663883,0.0005271673,0.0001105023,0.0007295518,0.0000492559,0.002597193],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001623039,"threshold_uncertainty_score":0.007783473,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03317067015618014,"score_gpt":0.3355746104633714,"score_spread":0.3024039403071913,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}