{"id":"W2043850625","doi":"10.1038/gt.2012.61","title":"Efficient transduction of myeloid cells by an HIV-1-derived lentiviral vector that packages the Vpx accessory protein","year":2012,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":102,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; U.S. Public Health Service; Oncolytics Biotech","keywords":"SAMHD1; Transduction (biophysics); Viral vector; Biology; Small hairpin RNA; Virology; Gene knockdown; Multiplicity of infection; Lentivirus; Genetic enhancement; Myeloid; RNA interference; Molecular biology; Cell culture; Gene; RNA; Cancer research; Virus; Reverse transcriptase; Genetics; Recombinant DNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003922932,0.0004465005,0.0002485609,0.0003100679,0.0002454867,0.0007734188,0.0002479668,0.0003524638,0.001130127],"category_scores_gemma":[0.0001919886,0.0001703745,0.0002558337,0.0002299575,0.0003240513,0.000396247,0.0003717512,0.001198247,0.0005506093],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005141471,"about_ca_system_score_gemma":0.0005604431,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004782909,"about_ca_topic_score_gemma":0.0006791863,"domain_scores_codex":[0.9997389,0.00004132119,0.00002304531,0.00003741919,0.00008816253,0.00007120349],"domain_scores_gemma":[0.999893,0.00001694715,0.00002762276,0.00002106847,0.00001327467,0.00002812285],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004572369,0.0000177502,0.0001016081,0.00001930277,0.000003972575,0.000043122,0.00002499482,0.00006972914,0.9961585,0.001331982,0.00005595882,0.002127496],"study_design_scores_gemma":[0.00001822313,0.00008348749,0.0007194983,0.000006602436,0.000009730568,0.0002288307,0.00001272908,0.0009234809,0.9932576,0.0002267989,0.004509146,0.000003850278],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9272683,0.001864791,0.06416501,0.0002768388,0.0001203258,0.0002608076,0.0009157981,0.0004014489,0.004726506],"genre_scores_gemma":[0.9668185,0.001008478,0.02469516,0.00005546043,0.00002434293,0.0001015244,0.0009034364,0.00007750731,0.006315673],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001130127,"threshold_uncertainty_score":0.003780663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02669010068619062,"score_gpt":0.2827094046993965,"score_spread":0.2560193040132059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}