{"id":"W2043850625","doi":"10.1038/gt.2012.61","title":"Efficient transduction of myeloid cells by an HIV-1-derived lentiviral vector that packages the Vpx accessory protein","year":2012,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":102,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; U.S. Public Health Service; Oncolytics Biotech","keywords":"SAMHD1; Transduction (biophysics); Viral vector; Biology; Small hairpin RNA; Virology; Gene knockdown; Multiplicity of infection; Lentivirus; Genetic enhancement; Myeloid; RNA interference; Molecular biology; Cell culture; Gene; RNA; Cancer research; Virus; Reverse transcriptase; Genetics; Recombinant DNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000586746,0.0002254942,0.0001788944,0.00004450526,0.0001411083,0.00002830703,0.0004405993,0.0001381885,0.000181059],"category_scores_gemma":[0.000005227718,0.0001639302,0.0001354155,0.0001187293,0.0001934089,0.00001000534,0.00003982572,0.000133913,0.00002176054],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001911082,"about_ca_system_score_gemma":0.00005961482,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001957386,"about_ca_topic_score_gemma":0.00001309598,"domain_scores_codex":[0.9982737,0.0004101458,0.000196739,0.0003222403,0.0003180696,0.0004790614],"domain_scores_gemma":[0.9990591,0.00001182031,0.0001101049,0.0006409215,0.00006940825,0.0001086279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001732032,0.0003422226,0.0001899622,0.000009330844,0.00009422443,2.158068e-7,0.0005021706,0.0001489188,0.9855775,0.000001748439,0.0003611216,0.01104057],"study_design_scores_gemma":[0.0009087936,0.001393485,0.001165401,0.000004496578,0.000008174047,0.000002059797,0.0001666282,0.00003306339,0.9927288,0.000007510765,0.003382954,0.0001985922],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925356,0.005304578,0.0007819508,0.0003322363,0.0001687217,0.000741446,0.00006251875,0.00002029398,0.00005265097],"genre_scores_gemma":[0.9978741,0.0007555364,0.00009636666,0.0001748986,0.0004011345,0.0001118768,0.0001207185,0.00005323934,0.0004121758],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01084198,"threshold_uncertainty_score":0.668488,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02669010068619062,"score_gpt":0.2827094046993965,"score_spread":0.2560193040132059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}