{"id":"W2043856061","doi":"10.1039/b801724g","title":"Linking the kinome and phosphorylome—a comprehensive review of approaches to find kinase targets","year":2008,"lang":"en","type":"review","venue":"Molecular BioSystems","topic":"Advanced Proteomics Techniques and Applications","field":"Chemistry","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research; National Cancer Institute; Genome Canada","keywords":"Kinome; Kinase; Phosphorylation; Biology; Computational biology; Protein phosphorylation; Cell biology; Protein kinase A","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004922046,0.001371681,0.001749733,0.003123999,0.0003890149,0.001186976,0.001404136,0.001353509,0.003895333],"category_scores_gemma":[0.0005174197,0.0005199101,0.0004504873,0.002781647,0.0006042724,0.002381906,0.0007489698,0.001558363,0.006266451],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008956293,"about_ca_system_score_gemma":0.0008418839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009921466,"about_ca_topic_score_gemma":0.001192573,"domain_scores_codex":[0.9997187,0.00003238666,0.00002712379,0.00005998406,0.0001409287,0.00002077595],"domain_scores_gemma":[0.9998048,0.00007609689,0.00002691256,0.000008059788,0.0000632831,0.00002088314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006593548,0.0001040922,0.0001458889,0.01448244,0.00008878709,0.0003888056,0.00007259782,0.0008006385,0.0145576,0.01120774,0.03300095,0.9250845],"study_design_scores_gemma":[0.00001309465,0.00007717874,0.0004830144,0.001257134,0.00004747205,0.001515945,0.00004773572,0.0002329692,0.003897462,0.005227287,0.9871671,0.00003370117],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002685514,0.9935866,0.002209479,0.0002723882,0.0002881568,0.00001446249,0.00003946327,0.0000469977,0.003273992],"genre_scores_gemma":[0.000835095,0.9938829,0.002545791,0.0002450349,0.0001671085,0.00002594499,0.00006059172,0.000007425803,0.002230165],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003895333,"threshold_uncertainty_score":0.01303124,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08146808433639019,"score_gpt":0.3015082796342897,"score_spread":0.2200401952978995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}