{"id":"W2043868350","doi":"10.1097/hco.0b013e328345986e","title":"Epigenetics in cardiovascular disease","year":2011,"lang":"en","type":"review","venue":"Current Opinion in Cardiology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; St. Michael's Hospital; University of Toronto","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Epigenetics; Chromatin; Histone; DNA methylation; Disease; Regulation of gene expression; Medicine; Chromatin remodeling; Epigenesis; Gene expression; Gene; Biology; Bioinformatics; Computational biology; Neuroscience; Genetics; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004829008,0.0009446195,0.00124413,0.0008891721,0.0002929868,0.0006887732,0.0008332026,0.001530431,0.004965481],"category_scores_gemma":[0.0005966029,0.0001695386,0.0003143178,0.001019695,0.0005264831,0.0009580709,0.0007390054,0.001538439,0.003153071],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005600324,"about_ca_system_score_gemma":0.0009415313,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007802942,"about_ca_topic_score_gemma":0.001062118,"domain_scores_codex":[0.9998554,0.00003482774,0.0000188972,0.00002689498,0.00005059535,0.00001337631],"domain_scores_gemma":[0.9997595,0.00008684809,0.00003958311,0.000008609554,0.00006912093,0.00003637786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000669258,0.00003519129,0.0002754871,0.007243548,0.00009416851,0.0004906654,0.00009843152,0.0004052653,0.004508669,0.006228318,0.06089617,0.9196571],"study_design_scores_gemma":[0.0000151629,0.00006420724,0.00122032,0.00163842,0.00006282362,0.002495159,0.00005700872,0.0001007937,0.0007710907,0.002934244,0.9906221,0.00001861881],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001490898,0.9966485,0.00029159,0.0009435972,0.0007580253,0.000005089849,0.00002001865,0.0000142398,0.001169836],"genre_scores_gemma":[0.001235941,0.995702,0.0002764973,0.0004292322,0.001088237,0.000006657465,0.00004115162,0.000002638665,0.001217765],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004965481,"threshold_uncertainty_score":0.01661122,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1254097790785465,"score_gpt":0.3779156686537313,"score_spread":0.2525058895751848,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}