{"id":"W2043881350","doi":"10.1002/cam4.111","title":"<scp>LRP</scp>5 knockdown: effect on prostate cancer invasion growth and skeletal metastasis <i>in vitro</i> and <i>in vivo</i>","year":2013,"lang":"en","type":"article","venue":"Cancer Medicine","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"","keywords":"Wnt signaling pathway; LRP5; Cancer research; Metastasis; Biology; Cell growth; Gene knockdown; Prostate cancer; Catenin; Cancer; Signal transduction; Cell biology; Cell culture; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003006454,0.0003040124,0.0003974328,0.0001234422,0.00005662435,0.00002025461,0.0001261008,0.0001411982,0.00006825326],"category_scores_gemma":[0.0001149723,0.0002286425,0.0000342456,0.00022167,0.0002124332,0.00001488929,0.00009001113,0.0001918937,0.000003245962],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004900569,"about_ca_system_score_gemma":0.00008064578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009776542,"about_ca_topic_score_gemma":0.0001780474,"domain_scores_codex":[0.9984044,0.00008954742,0.000300101,0.0005806243,0.000216099,0.0004092431],"domain_scores_gemma":[0.999431,0.00008269917,0.00009855087,0.0001750208,0.00005858863,0.0001541377],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001264369,0.00002265487,0.0263451,0.0001702419,0.00005214526,0.000009153085,0.0003142694,0.00001297104,0.945815,0.000004283199,0.01371722,0.01341056],"study_design_scores_gemma":[0.003701466,0.0005750092,0.01325322,0.0004421574,0.00005383605,0.000008511915,0.0001343359,0.00002965775,0.9580171,0.00006502694,0.0235192,0.0002004487],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9751043,0.02193991,0.000005526531,0.001014164,0.0002992067,0.0005843841,0.00002317736,0.00001288,0.001016456],"genre_scores_gemma":[0.9848558,0.01127619,0.0000589412,0.001809476,0.0003295122,0.0006627577,0.00004492246,0.00003677736,0.0009256297],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01321011,"threshold_uncertainty_score":0.9323772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006842504341687991,"score_gpt":0.239895230650338,"score_spread":0.23305272630865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}