{"id":"W2043909083","doi":"10.1021/cn400028w","title":"Biological Activity of <i>sym</i>-Triazines with Acetylcholine-like Substitutions as Multitarget Modulators of Alzheimer’s Disease","year":2013,"lang":"en","type":"article","venue":"ACS Chemical Neuroscience","topic":"Synthesis and Characterization of Heterocyclic Compounds","field":"Chemistry","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Synaptophysin; Acetylcholinesterase; Thioflavin; Chemistry; Acetylcholine; Fibrillogenesis; Pentapeptide repeat; Triazine; Aché; Butyrylcholinesterase; Cell biology; Amyloid (mycology); Biochemistry; Fibril; Alzheimer's disease; Biophysics; Molecular biology; Biology; Pharmacology; Internal medicine; Peptide; Enzyme; Disease; Immunohistochemistry; Medicine; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005023565,0.0001862218,0.0002824577,0.00004946184,0.0000691622,0.00002460286,0.000417344,0.00007930398,0.0001679965],"category_scores_gemma":[0.0003196699,0.0001364592,0.00009458888,0.0002884605,0.0006793166,0.0002635288,0.0001373513,0.0001305847,0.000007952395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000114915,"about_ca_system_score_gemma":0.00005427854,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002685928,"about_ca_topic_score_gemma":1.928821e-7,"domain_scores_codex":[0.9986629,0.0000199327,0.0003055267,0.000429748,0.0003331843,0.0002486728],"domain_scores_gemma":[0.9989084,0.0001199042,0.0002143101,0.0004285213,0.0001132418,0.0002156206],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005034325,0.000313727,0.01038749,0.00001900138,0.000006093162,0.000001530112,0.00001438765,0.00002138414,0.9886805,0.00007869997,0.00003817501,0.000388705],"study_design_scores_gemma":[0.0002771754,0.0000215389,0.02646597,0.00003037829,0.00002252477,0.00000608244,0.000006523185,0.0006735909,0.9717405,0.00004263483,0.0005516752,0.000161424],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999051,0.00003618717,0.00007396781,0.0002384421,0.00007026014,0.00009958088,0.0000435574,0.00005164595,0.0003353035],"genre_scores_gemma":[0.9994905,0.00003765139,0.0001885163,0.000135688,0.00003718744,0.00003164878,0.00001121667,0.00001133617,0.00005624827],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01693998,"threshold_uncertainty_score":0.5564644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02864807963362663,"score_gpt":0.2518805829622113,"score_spread":0.2232325033285847,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}