{"id":"W2043911972","doi":"10.1002/(sici)1097-0290(20000720)69:2<204::aid-bit9>3.0.co;2-z","title":"Limitations to the amplification and stability of human tissue-type plasminogen activator expression by Chinese hamster ovary cells","year":2000,"lang":"en","type":"article","venue":"Biotechnology and Bioengineering","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Chinese hamster ovary cell; Molecular biology; Plasminogen activator; Biology; T-plasminogen activator; Cell culture; Complementary DNA; Subcloning; Microgram; Tissue plasminogen activator; Recombinant DNA; In vitro; Endocrinology; Biochemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004961668,0.0001030495,0.00008528931,0.00003216995,0.0001131824,0.00001043248,0.00008631528,0.0001845467,0.00002034877],"category_scores_gemma":[0.00002001837,0.0000738542,0.00001789554,0.00009443023,0.00007958445,0.000005275811,0.00006549941,0.00006508578,0.000001960297],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003813777,"about_ca_system_score_gemma":0.000006007813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001248809,"about_ca_topic_score_gemma":0.0000062106,"domain_scores_codex":[0.9994959,0.00001646473,0.0001209731,0.0002183095,0.00003977182,0.0001085994],"domain_scores_gemma":[0.9996569,0.00001186862,0.00002884003,0.0002344528,0.00002210734,0.00004581515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003196605,0.00003009403,0.00102027,0.00001501265,0.00001300908,1.333293e-7,0.00004486685,0.00002906839,0.9951356,0.00001409048,0.0007040847,0.002961789],"study_design_scores_gemma":[0.0001138117,0.0002575647,0.002835423,0.00001036665,0.000007343878,0.000002631014,0.0000339555,0.00004037503,0.9875987,0.00001639171,0.008991012,0.0000924341],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983283,0.0006860563,0.0004059873,0.0002591791,0.00005566519,0.0001637382,0.00003115617,0.00002715107,0.00004279452],"genre_scores_gemma":[0.9989166,0.0006293214,0.0002641885,0.00004370146,0.00003540151,0.00001814168,0.00003268405,0.000008782065,0.00005114317],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008286928,"threshold_uncertainty_score":0.3011687,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01395236639231321,"score_gpt":0.2440886946954828,"score_spread":0.2301363283031696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}