{"id":"W2043935805","doi":"10.1016/j.molimm.2014.01.008","title":"Inducible costimulator facilitates T-dependent B cell activation by augmenting IL-4 translation","year":2014,"lang":"en","type":"article","venue":"Molecular Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research","keywords":"Germinal center; PI3K/AKT/mTOR pathway; Cell biology; T cell; Population; Signal transduction; Chemistry; Biology; B cell; Immune system; Immunology; Antibody; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004054731,0.0004044039,0.0004855457,0.0002345001,0.0003540993,0.00003351236,0.0004391015,0.0007854264,0.0006139033],"category_scores_gemma":[0.0001033175,0.0004112863,0.0001631046,0.000213204,0.0003176262,0.0001752497,0.0001329907,0.0006885781,0.001422602],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008708942,"about_ca_system_score_gemma":0.00005136117,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002203209,"about_ca_topic_score_gemma":0.00000515886,"domain_scores_codex":[0.9971338,0.0006968623,0.0005834819,0.0007083873,0.00007498707,0.0008024808],"domain_scores_gemma":[0.9987185,0.0002578593,0.0002599884,0.0006266932,0.0001060192,0.00003096895],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001511485,0.0002621293,0.0001734391,0.00001904478,0.0002343801,0.000002970027,0.0003065825,0.0000615537,0.984197,0.0003827699,0.0008458846,0.01336307],"study_design_scores_gemma":[0.002898217,0.0004483958,0.0001298469,0.00001538621,0.00005845251,0.00003012518,0.00016019,0.00004372149,0.9124008,0.000400105,0.08303016,0.0003846213],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9727489,0.005383448,0.01647171,0.000599459,0.0009199074,0.0004366469,0.0000397196,0.0002434982,0.003156759],"genre_scores_gemma":[0.9958541,0.00008076936,0.0002327886,0.0003729689,0.00001811002,0.00006361708,0.0007142047,0.00005076903,0.002612698],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08218427,"threshold_uncertainty_score":0.9998339,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009458793153808093,"score_gpt":0.2105478945594785,"score_spread":0.2010891014056704,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}