{"id":"W2043999650","doi":"10.1038/ncomms5619","title":"Matrix softness regulates plasticity of tumour-repopulating cells via H3K9 demethylation and Sox2 expression","year":2014,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":202,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; University of Illinois at Urbana-Champaign; Howard Hughes Medical Institute; National Science Foundation; National Institutes of Health; Huazhong University of Science and Technology","keywords":"SOX2; Cell biology; Cancer research; Biology; Cancer cell; Epigenetics; Chemistry; Cancer; Embryonic stem cell; Biochemistry; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007113897,0.0002076672,0.0001171754,0.0001263346,0.0001484665,0.0002468475,0.0001094738,0.0001452555,0.001429371],"category_scores_gemma":[0.00007924157,0.0001296517,0.0002133035,0.00008519737,0.0001978555,0.0001444699,0.0001981687,0.000335229,0.000246945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001936026,"about_ca_system_score_gemma":0.000132695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008443668,"about_ca_topic_score_gemma":0.001371513,"domain_scores_codex":[0.9999188,0.000009822045,0.000007335327,0.0000203127,0.0000226113,0.00002100201],"domain_scores_gemma":[0.999921,0.000008434792,0.00003139305,0.000006503324,0.00001011597,0.00002261191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005652575,0.000007252172,0.0005215418,0.0000161385,0.000003912373,0.00003189444,0.00001595334,0.00003292085,0.9984296,0.00004628132,0.00001892572,0.000819049],"study_design_scores_gemma":[0.0000125415,0.00009841442,0.03058948,0.000004765785,0.00001532604,0.0001347298,0.00005998297,0.0009072062,0.9665334,0.00008522267,0.001553774,0.000005130711],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949108,0.001343271,0.001957512,0.0000805051,0.00002550579,0.00001498253,0.0002120992,0.0000615934,0.001393815],"genre_scores_gemma":[0.9973053,0.0004581115,0.0004403062,0.00003058718,0.000004282556,0.00001111956,0.0001198655,0.000007488167,0.001622984],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001429371,"threshold_uncertainty_score":0.004781723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.017695366856325,"score_gpt":0.3150095580340962,"score_spread":0.2973141911777712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}