{"id":"W2044025778","doi":"10.1038/nrm2466","title":"The promise of human induced pluripotent stem cells for research and therapy","year":2008,"lang":"en","type":"review","venue":"Nature Reviews Molecular Cell Biology","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":419,"is_retracted":false,"has_abstract":false,"ca_institutions":"Juvenile Diabetes Research Foundation","funders":"","keywords":"Induced pluripotent stem cell; Reprogramming; Embryonic stem cell; Regenerative medicine; Somatic cell; Human Induced Pluripotent Stem Cells; Stem cell; Biology; Cell therapy; Cell potency; Cell biology; Cell; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.002302787,0.0007596422,0.00216702,0.0002662314,0.0004694619,0.0000438526,0.001516055,0.002501108,0.000003647646],"category_scores_gemma":[0.0001518323,0.0004606314,0.001053402,0.0004553314,0.0006845725,0.000003273269,0.0006539342,0.001814316,0.00001458355],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006048164,"about_ca_system_score_gemma":0.0005034209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007449711,"about_ca_topic_score_gemma":0.000005133768,"domain_scores_codex":[0.9934129,0.00248229,0.001308367,0.001391272,0.0003812048,0.001023966],"domain_scores_gemma":[0.996442,0.0003339484,0.0007919748,0.001664856,0.0005473724,0.0002199072],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004722966,0.0001088081,8.558733e-7,0.005534609,0.0001925944,0.000008141907,0.000007149598,5.175187e-8,0.2823434,0.0001176012,0.001942269,0.7096974],"study_design_scores_gemma":[0.0005001536,0.001402577,1.089271e-7,0.0009804603,0.00006645174,0.00002772514,0.000005871378,5.438685e-7,0.08268777,0.00005421328,0.9138911,0.0003829737],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007075252,0.9906872,0.00002519211,0.00003581676,0.0002268998,0.00768332,0.0000840452,0.000008995811,0.0005409993],"genre_scores_gemma":[0.0002848818,0.9963359,0.0001703201,0.0000481474,0.0002330837,0.001351,0.0003850782,0.0001338153,0.00105777],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9119489,"threshold_uncertainty_score":0.9997845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.109004600548994,"score_gpt":0.4171959208418612,"score_spread":0.3081913202928672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}