{"id":"W2044138588","doi":"10.1126/science.1189369","title":"Beyond Access vs. Protection in Trials of Innovative Therapies","year":2010,"lang":"en","type":"article","venue":"Science","topic":"Biomedical Ethics and Regulation","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Center for Research Resources; Canadian Institutes of Health Research","keywords":"Clinical trial; Safeguard; Focus (optics); Quality (philosophy); Business; Medicine; Risk analysis (engineering); Intensive care medicine; Internal medicine; International trade","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003793785,0.00002985386,0.0001313881,0.000210868,0.00003673136,0.0000135538,0.00009480229,0.00006487352,0.0000583198],"category_scores_gemma":[0.001068299,0.00001805417,0.00001329165,0.001600393,0.001562192,0.0001409338,0.00002744435,0.000202253,9.602267e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001069703,"about_ca_system_score_gemma":0.0002927449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004969383,"about_ca_topic_score_gemma":0.00003435255,"domain_scores_codex":[0.9992645,0.0000225444,0.0002128433,0.0001072712,0.0003178713,0.00007498276],"domain_scores_gemma":[0.9994826,0.00004020104,0.0001075663,0.00009242038,0.0002487474,0.0000284245],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00004172782,0.00003632441,0.002253084,0.00001862267,0.000001710963,3.172322e-7,0.0006261219,3.493427e-7,0.9024287,0.007593517,0.000006168393,0.08699338],"study_design_scores_gemma":[0.0006437518,0.0001447958,0.6642888,0.00005685084,0.000002353924,0.00000323488,0.00008335678,0.0003977687,0.3021624,0.03118354,0.0009920655,0.00004113169],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873467,0.00002012121,0.0004456097,0.01049097,0.0003546316,0.0003021299,9.571905e-7,0.000007076166,0.001031773],"genre_scores_gemma":[0.9992306,0.000005883909,0.0005022555,0.0001488853,0.0000525328,0.000007797137,6.813655e-7,0.00000141942,0.00004997071],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6620357,"threshold_uncertainty_score":0.5755962,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08847474982351489,"score_gpt":0.4189739197439493,"score_spread":0.3304991699204344,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}