{"id":"W2044138588","doi":"10.1126/science.1189369","title":"Beyond Access vs. Protection in Trials of Innovative Therapies","year":2010,"lang":"en","type":"article","venue":"Science","topic":"Biomedical Ethics and Regulation","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Center for Research Resources; Canadian Institutes of Health Research","keywords":"Clinical trial; Safeguard; Focus (optics); Quality (philosophy); Business; Medicine; Risk analysis (engineering); Intensive care medicine; Internal medicine; International trade","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.5004961,0.001238598,0.005040247,0.003230907,0.003199772,0.01530163,0.005206772,0.03501577,0.007795031],"category_scores_gemma":[0.6102468,0.001600614,0.003481516,0.003044885,0.02969437,0.02821587,0.01249704,0.02164908,0.002318799],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006419122,"about_ca_system_score_gemma":0.02064518,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001054236,"about_ca_topic_score_gemma":0.001070404,"domain_scores_codex":[0.5371135,0.347277,0.03329147,0.02021841,0.05597569,0.006123946],"domain_scores_gemma":[0.2018001,0.6615716,0.04391272,0.06173426,0.023674,0.007307306],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.001432078,0.0001079395,0.002268234,0.003378631,0.0005617858,0.0002780579,0.002560295,0.0008919576,0.001097238,0.8937514,0.01223123,0.08144105],"study_design_scores_gemma":[0.0009561147,0.0006927456,0.002474905,0.003974283,0.0004141691,0.0005326421,0.0003244713,0.0009963746,0.001173163,0.8981693,0.09017477,0.000117148],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.01762718,0.08662751,0.1614417,0.5909886,0.008981958,0.002098983,0.0007955061,0.0003339026,0.1311048],"genre_scores_gemma":[0.6339276,0.02042316,0.05282722,0.2491127,0.02407027,0.005816211,0.000272454,0.0002679419,0.01328234],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.4995039,"threshold_uncertainty_score":0.6159772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08847474982351489,"score_gpt":0.4189739197439493,"score_spread":0.3304991699204344,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}