{"id":"W2044161850","doi":"10.1124/dmd.112.044891","title":"Hepatobiliary Disposition of 17-OHPC and Taurocholate in Fetal Human Hepatocytes: A Comparison with Adult Human Hepatocytes","year":2012,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; National Institutes of Health","keywords":"Multidrug resistance-associated protein 2; Fetus; Taurocholic acid; Efflux; Endocrinology; Internal medicine; Hepatocyte; Abcg2; Biology; Pharmacology; Medicine; Transporter; ATP-binding cassette transporter; Biochemistry; Bile acid; Pregnancy; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000313052,0.0003252046,0.0007318349,0.0002422036,0.0002088156,0.00003168789,0.00006369708,0.0001319994,0.00002917924],"category_scores_gemma":[0.000006405162,0.0002560497,0.00009247863,0.0001997319,0.0001984368,0.000526784,0.00002787437,0.000262601,0.000002553175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003132499,"about_ca_system_score_gemma":0.00002167215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000430195,"about_ca_topic_score_gemma":0.0003305404,"domain_scores_codex":[0.9982207,0.00008601023,0.0005441411,0.0003793067,0.0003555534,0.000414317],"domain_scores_gemma":[0.9990994,0.00002557702,0.000243155,0.0002518068,0.0001046472,0.0002754498],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001277234,0.001440338,0.8267583,0.0007780665,0.0001104257,0.00003814235,0.005016669,0.000004122961,0.1491303,0.01337959,0.00005344539,0.002013301],"study_design_scores_gemma":[0.004461373,0.0002194008,0.9475482,0.0007227755,0.0005927299,0.00005375021,0.00111969,0.0003224231,0.043932,0.0004645033,0.0001730206,0.0003901209],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933719,0.004521335,0.0005304292,0.0001003602,0.00008041274,0.0006991962,0.00005136675,0.00005969173,0.0005853088],"genre_scores_gemma":[0.9981897,0.0002482168,0.0006130391,0.0001311567,0.0001476608,0.00006979163,0.0004478548,0.00003880693,0.0001137038],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1207899,"threshold_uncertainty_score":0.9999892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009194427806586919,"score_gpt":0.258802903899536,"score_spread":0.2496084760929491,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}