{"id":"W2044161850","doi":"10.1124/dmd.112.044891","title":"Hepatobiliary Disposition of 17-OHPC and Taurocholate in Fetal Human Hepatocytes: A Comparison with Adult Human Hepatocytes","year":2012,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; National Institutes of Health","keywords":"Multidrug resistance-associated protein 2; Fetus; Taurocholic acid; Efflux; Endocrinology; Internal medicine; Hepatocyte; Abcg2; Biology; Pharmacology; Medicine; Transporter; ATP-binding cassette transporter; Biochemistry; Bile acid; Pregnancy; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001480813,0.0001318212,0.0001452933,0.0002761379,0.0001747125,0.0002970503,0.0001058142,0.0001487725,0.001473347],"category_scores_gemma":[0.0002402619,0.00008243928,0.0001693198,0.0002774669,0.0001792146,0.0002979454,0.0001268992,0.0001759146,0.0003282252],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002576738,"about_ca_system_score_gemma":0.0001984641,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004791175,"about_ca_topic_score_gemma":0.002299229,"domain_scores_codex":[0.9999317,0.00001620981,0.0000087639,0.00001171292,0.00001354923,0.00001800592],"domain_scores_gemma":[0.9998741,0.00003609126,0.00001453703,0.00002175941,0.0000277073,0.0000258394],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008244887,0.00007999213,0.01756861,0.0001341774,0.00004216978,0.001391095,0.0003944717,0.0002517433,0.9532535,0.00038808,0.0001757667,0.01807557],"study_design_scores_gemma":[0.00005339668,0.002083329,0.1250937,0.00001296372,0.0001180445,0.003102041,0.0007542936,0.001179617,0.8627908,0.0001126511,0.004678862,0.00002033216],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942219,0.002652861,0.0009116528,0.000040105,0.00001962494,0.000007404648,0.0003769954,0.00002382607,0.001745617],"genre_scores_gemma":[0.9971732,0.0008129849,0.0003848602,0.00001739883,0.00000645739,0.000007727016,0.0004149467,0.000008062374,0.001174452],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004791175,"threshold_uncertainty_score":0.009526551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009194427806586919,"score_gpt":0.258802903899536,"score_spread":0.2496084760929491,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}