{"id":"W2044166564","doi":"10.1007/s10549-011-1692-y","title":"Inhibition of aldehyde dehydrogenase (ALDH) activity reduces chemotherapy and radiation resistance of stem-like ALDHhiCD44+ human breast cancer cells","year":2011,"lang":"en","type":"article","venue":"Breast Cancer Research and Treatment","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":328,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Ontario Ministry of Research and Innovation; Canadian Institutes of Health Research","keywords":"Aldehyde dehydrogenase; Breast cancer; Cancer stem cell; Cancer; Chemotherapy; Cancer research; Medicine; Stem cell; Oncology; Internal medicine; Biology; Enzyme; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002654662,0.0002192063,0.0004752238,0.0002099706,0.0001422578,0.00001518755,0.00004974332,0.0000846667,0.0003472775],"category_scores_gemma":[0.000001251342,0.0001732418,0.00008577087,0.0002995207,0.0003911874,0.0001386351,0.00003408928,0.000126549,9.943097e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003987597,"about_ca_system_score_gemma":0.0003566204,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01975136,"about_ca_topic_score_gemma":0.003276157,"domain_scores_codex":[0.9983419,0.0001041816,0.0002817817,0.0004475302,0.0004484031,0.000376208],"domain_scores_gemma":[0.9989207,0.00003834429,0.0001797861,0.0002871316,0.000288374,0.0002856993],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006975969,0.001718875,0.01398908,0.0005522151,0.0006544949,0.00003368484,0.001824857,0.000001241086,0.6945702,0.0001004926,0.0005649283,0.2790139],"study_design_scores_gemma":[0.004337277,0.0006584951,0.1248027,0.0004193879,0.0001477962,0.00003647703,0.0002217118,0.000005091355,0.8684943,0.00006276844,0.0006771666,0.0001368485],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909209,0.00590777,0.000003693898,0.0007439846,0.00004754708,0.0007750744,0.00112219,0.00001493331,0.000463914],"genre_scores_gemma":[0.9785093,0.02016129,0.00008197944,0.00002707817,0.0001122288,0.0002390069,0.00001636519,0.00002995373,0.0008227653],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2788771,"threshold_uncertainty_score":0.9867762,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06497320140829642,"score_gpt":0.3488083949856305,"score_spread":0.2838351935773341,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}