{"id":"W2044168459","doi":"10.1242/jcs.085795","title":"WDR36 acts as a scaffold protein tethering a G-protein-coupled receptor, Gαq and phospholipase Cβ in a signalling complex","year":2011,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Biology; Cell biology; Scaffold protein; Immunoprecipitation; G protein-coupled receptor; Gq alpha subunit; Gene knockdown; Colocalization; G protein; HEK 293 cells; Proximity ligation assay; Receptor; Context (archaeology); Phospholipase; Signal transduction; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00134288,0.0001484571,0.000203588,0.0001320069,0.0001216767,0.00007024561,0.0003702512,0.00008427218,0.0001927713],"category_scores_gemma":[0.0001171397,0.0001244675,0.00007011442,0.000263321,0.0001618222,0.0000349355,0.0001194197,0.000163461,0.000004445538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000323292,"about_ca_system_score_gemma":0.0002525098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006851954,"about_ca_topic_score_gemma":0.00001091818,"domain_scores_codex":[0.9986148,0.00004291599,0.0003783152,0.000277904,0.0003443589,0.0003416868],"domain_scores_gemma":[0.9991629,0.000007600797,0.0003194713,0.0001287735,0.0001669697,0.0002142961],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001364362,0.000067915,0.00006496021,0.00001561529,0.000005234507,0.00001908139,0.0003729543,0.00003363871,0.9984488,0.00006801546,0.000004846387,0.0007624879],"study_design_scores_gemma":[0.0005907175,0.0006300187,0.0001161998,0.0001281317,0.000005021703,0.00003741285,0.0002997227,0.0006270669,0.9965341,0.0003150023,0.0005532287,0.0001633825],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963449,0.0004150191,0.002119851,0.00003412643,0.00008185181,0.0002078971,6.658677e-7,0.000003436991,0.0007922032],"genre_scores_gemma":[0.9836288,0.00007069171,0.01599164,0.00006531551,0.00008410891,0.000005940486,4.516483e-7,0.00001395272,0.0001390769],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01387178,"threshold_uncertainty_score":0.5075639,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02235000195181441,"score_gpt":0.2378485831241643,"score_spread":0.2154985811723499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}