{"id":"W2044168459","doi":"10.1242/jcs.085795","title":"WDR36 acts as a scaffold protein tethering a G-protein-coupled receptor, Gαq and phospholipase Cβ in a signalling complex","year":2011,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Biology; Cell biology; Scaffold protein; Immunoprecipitation; G protein-coupled receptor; Gq alpha subunit; Gene knockdown; Colocalization; G protein; HEK 293 cells; Proximity ligation assay; Receptor; Context (archaeology); Phospholipase; Signal transduction; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001387976,0.0004142053,0.0003973922,0.0002564912,0.0002608252,0.0002771092,0.0003459946,0.0002896313,0.0008939566],"category_scores_gemma":[0.0001160806,0.0001603304,0.0005173637,0.0002294144,0.0002079057,0.0002582535,0.000392551,0.0003285276,0.0005057339],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004681587,"about_ca_system_score_gemma":0.000115171,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006594,"about_ca_topic_score_gemma":0.0008415242,"domain_scores_codex":[0.9998407,0.00002415238,0.00002080992,0.00005717362,0.00002847847,0.00002852487],"domain_scores_gemma":[0.9999232,0.000006354615,0.00002949172,0.00001285245,0.000008191306,0.00001988563],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006704205,0.000007090623,0.0003171982,0.00003463403,0.000009072437,0.0001287987,0.00001614418,0.00005328258,0.99882,0.00008562641,0.00002370824,0.0004374108],"study_design_scores_gemma":[0.00002022214,0.0001194443,0.006312449,0.000007309246,0.00003599099,0.001039727,0.00003470786,0.001951157,0.9865103,0.0000692696,0.003890801,0.000008493725],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932978,0.001307359,0.004291627,0.0001001099,0.00001901169,0.00002473551,0.0003895762,0.0001014269,0.0004682946],"genre_scores_gemma":[0.9905412,0.0006278743,0.0060811,0.00004519509,0.000007971522,0.00002099199,0.0007931283,0.00001934878,0.001863107],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008939566,"threshold_uncertainty_score":0.003396809,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02235000195181441,"score_gpt":0.2378485831241643,"score_spread":0.2154985811723499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}