{"id":"W2044174375","doi":"10.1002/prot.20946","title":"Modeling and functional analysis of AEBP1, a transcriptional repressor","year":2006,"lang":"en","type":"article","venue":"Proteins Structure Function and Bioinformatics","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; Institute for Marine Biosciences; Dalhousie University","funders":"","keywords":"Repressor; Chemistry; DNA-binding domain; Electrophoretic mobility shift assay; GATAD2B; Transcription (linguistics); Molecular biology; Psychological repression; Transcription factor; Lac repressor; Transcriptional regulation; YY1; Biochemistry; Gene expression; Gene; Biology; Promoter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008696313,0.000128248,0.0002964991,0.0004692354,0.0001028023,0.00002831695,0.00001455898,0.00009880598,0.0002637092],"category_scores_gemma":[0.00001773821,0.00009879218,0.0001383982,0.0005182231,0.0000732304,0.0001565674,0.00001278037,0.0001170426,8.569324e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001547462,"about_ca_system_score_gemma":0.00002726525,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004976822,"about_ca_topic_score_gemma":0.00004629263,"domain_scores_codex":[0.9990274,0.00001146385,0.0004269328,0.0001401485,0.0002825848,0.0001115253],"domain_scores_gemma":[0.9995505,0.000009997913,0.0001048072,0.0001228176,0.0001504898,0.00006141273],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.005469577,0.001169204,0.1076564,0.005531691,0.01345969,0.00001598594,0.002564774,0.09767656,0.6148369,0.08425537,0.001872955,0.06549082],"study_design_scores_gemma":[0.001358034,0.0001172115,0.04921939,0.00008791091,0.002025003,0.00004133386,0.000338408,0.9433987,0.001145463,0.001837488,0.0002723783,0.0001586857],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7040203,0.0002160452,0.2936686,0.0005596001,0.00003067799,0.0002871392,0.0001515731,0.00007658102,0.0009895434],"genre_scores_gemma":[0.9897894,0.00001563638,0.009258722,0.0002213417,0.00005670374,0.000007072438,0.0004694387,0.000005420364,0.0001762461],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8457221,"threshold_uncertainty_score":0.4028628,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0116128164328509,"score_gpt":0.2153705885585441,"score_spread":0.2037577721256932,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}