{"id":"W2044177284","doi":"10.1016/j.neuropharm.2013.05.002","title":"Connexin43 confers Temozolomide resistance in human glioma cells by modulating the mitochondrial apoptosis pathway","year":2013,"lang":"en","type":"article","venue":"Neuropharmacology","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":119,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Temozolomide; Glioma; Apoptosis; Cancer research; Gene knockdown; Annexin; Biology; DNA damage; DNA repair; Intrinsic apoptosis; Programmed cell death; Caspase; DNA; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001382698,0.0002595076,0.0002676794,0.00006790887,0.0001871714,0.00003479723,0.0004463925,0.0002430667,0.0003433605],"category_scores_gemma":[0.00007913613,0.0002109417,0.000103831,0.0001454365,0.0002958848,0.00000691153,0.0001915882,0.0003009326,0.00005098179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002118429,"about_ca_system_score_gemma":0.00005140888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001490798,"about_ca_topic_score_gemma":0.0001167412,"domain_scores_codex":[0.9978475,0.0004947697,0.0004152934,0.000613953,0.00009208353,0.000536402],"domain_scores_gemma":[0.9991539,0.0001248962,0.0001570467,0.0003800975,0.00008572243,0.00009832068],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001185893,0.0000661322,0.0003107874,0.000008217839,0.00002830376,0.00001055179,0.00004380423,0.00002631311,0.9728876,0.0001432636,0.0258513,0.0005051537],"study_design_scores_gemma":[0.001695669,0.0003050219,0.0008037519,0.000003921711,0.00001389838,0.000008406162,0.00006043392,0.00006333544,0.9000621,0.0001175314,0.09660871,0.0002572626],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995351,0.0003318344,0.00005145436,0.001265944,0.000848293,0.0006114247,0.00003008003,0.00002366941,0.00148634],"genre_scores_gemma":[0.9953761,0.00005665502,0.0001304013,0.002651814,0.0004142258,0.0001810575,0.00005013893,0.00003820889,0.001101456],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07282552,"threshold_uncertainty_score":0.8601953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00807761003150389,"score_gpt":0.2414992662796411,"score_spread":0.2334216562481372,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}