{"id":"W2044248453","doi":"10.1089/jir.2012.0058","title":"Engagement of CD14 Sensitizes Primary Monocytes to IFN-γ to Produce IL-12/23p40 and IL-23 Through p38 Mitogen-Activated Protein Kinase and Independent of the Janus Kinase/Signal Transducers and Activators of Transcription Signaling","year":2013,"lang":"en","type":"article","venue":"Journal of Interferon & Cytokine Research","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Children's Hospital of Eastern Ontario; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"p38 mitogen-activated protein kinases; CD14; Janus kinase; Kinase; stat; Cell biology; JAK-STAT signaling pathway; Signal transduction; STAT protein; Interleukin 12; Biology; Chemistry; Protein kinase A; Molecular biology; Immune system; STAT3; Immunology; Tyrosine kinase; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001327639,0.0002381179,0.0005942773,0.000398949,0.0001433328,0.000025578,0.0002289787,0.0001620864,0.00005898501],"category_scores_gemma":[0.0001351133,0.0001630146,0.0001226708,0.0002902338,0.0002941919,0.0002318886,0.0001361265,0.0005002492,0.000001785001],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001135691,"about_ca_system_score_gemma":0.0001471997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003540195,"about_ca_topic_score_gemma":0.00002369888,"domain_scores_codex":[0.9973557,0.0009823053,0.0007150144,0.0003116639,0.0002801363,0.000355163],"domain_scores_gemma":[0.9985682,0.0002638419,0.000313438,0.0002243175,0.0005428148,0.00008736616],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004908409,0.0002607793,0.0009552162,0.0002599366,0.0005638559,0.00000741236,0.006544515,0.00001645841,0.9692743,0.00001277517,0.0001173887,0.01707892],"study_design_scores_gemma":[0.002120652,0.003347358,0.02072183,0.0006779359,0.0001018161,0.00005792649,0.002637821,0.000001701594,0.9699516,0.00005080663,0.0002002346,0.0001302617],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99638,0.001200307,0.0001030816,0.0008385449,0.0001323614,0.001240971,0.0000674137,0.000005322574,0.00003197267],"genre_scores_gemma":[0.9992127,0.0002078681,0.00032297,0.00002136073,0.0000435246,0.00003681065,0.00000511026,0.00002199112,0.0001276387],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01976661,"threshold_uncertainty_score":0.6647545,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05125649423373745,"score_gpt":0.2910697597288573,"score_spread":0.2398132654951198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}