{"id":"W2044248453","doi":"10.1089/jir.2012.0058","title":"Engagement of CD14 Sensitizes Primary Monocytes to IFN-γ to Produce IL-12/23p40 and IL-23 Through p38 Mitogen-Activated Protein Kinase and Independent of the Janus Kinase/Signal Transducers and Activators of Transcription Signaling","year":2013,"lang":"en","type":"article","venue":"Journal of Interferon & Cytokine Research","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Children's Hospital of Eastern Ontario; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"p38 mitogen-activated protein kinases; CD14; Janus kinase; Kinase; stat; Cell biology; JAK-STAT signaling pathway; Signal transduction; STAT protein; Interleukin 12; Biology; Chemistry; Protein kinase A; Molecular biology; Immune system; STAT3; Immunology; Tyrosine kinase; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001213663,0.000404039,0.0002581329,0.0001758228,0.0001574821,0.0003343392,0.0001542357,0.0002336071,0.00233791],"category_scores_gemma":[0.0001665603,0.0002000862,0.000303792,0.0001093521,0.0001833911,0.000104743,0.0002350639,0.0006499782,0.0006388132],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002985018,"about_ca_system_score_gemma":0.0003198787,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008450776,"about_ca_topic_score_gemma":0.001461418,"domain_scores_codex":[0.9996767,0.00004865083,0.00003272658,0.00004207075,0.00006102129,0.0001388277],"domain_scores_gemma":[0.9998932,0.00001851017,0.00001875253,0.00001713195,0.00001691337,0.00003552663],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002566689,0.00003891281,0.0002427393,0.00003027327,0.000003531951,0.00006625886,0.00001624179,0.00002847612,0.9983109,0.00003818434,0.00003754047,0.0009301726],"study_design_scores_gemma":[0.00004887892,0.0004919847,0.006729774,0.00001221625,0.00001741303,0.0002550693,0.00004315154,0.0006330381,0.989127,0.0000447938,0.002591631,0.000004925511],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959025,0.0006375285,0.00150069,0.00009137466,0.00006358936,0.00006481844,0.0002537965,0.00003393858,0.001451836],"genre_scores_gemma":[0.9931826,0.0007022811,0.002319959,0.0001330661,0.0000288935,0.0000913808,0.0006538375,0.000009929196,0.002878075],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00233791,"threshold_uncertainty_score":0.007821083,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05125649423373745,"score_gpt":0.2910697597288573,"score_spread":0.2398132654951198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}