{"id":"W2044287047","doi":"10.3747/co.19.1281","title":"Targeting the Androgen Receptor in the Management of Castration-Resistant Prostate Cancer: Rationale, Progress, and Future Directions","year":2012,"lang":"en","type":"article","venue":"Current Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Enzalutamide; Prostate cancer; Medicine; Abiraterone acetate; Androgen receptor; Disease; Clinical trial; Abiraterone; Hormonal therapy; Cancer; Bioinformatics; Oncology; Cancer research; Pharmacology; Androgen deprivation therapy; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003970086,0.00007630111,0.0001242777,0.00004212843,0.000125886,0.000009060452,0.0000550323,0.00003245137,0.00005625407],"category_scores_gemma":[0.00000508106,0.00003807719,0.00002481101,0.0002148875,0.000157321,0.00005742382,0.00002786883,0.000156315,0.000002092672],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001206792,"about_ca_system_score_gemma":0.0001078899,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000013383,"about_ca_topic_score_gemma":0.00002805979,"domain_scores_codex":[0.9992274,0.0001105684,0.0001749554,0.0001104612,0.0001698697,0.0002067633],"domain_scores_gemma":[0.9996686,0.00005168827,0.00007171416,0.00009713587,0.00006796565,0.00004291491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009471322,0.001471863,0.4402789,0.0007732032,0.0003074714,0.00001530874,0.01451828,0.000002629832,0.000626471,0.004046788,0.009634318,0.5273775],"study_design_scores_gemma":[0.001540144,0.0002085212,0.1310043,0.00009383755,0.0001088351,0.00001123736,0.00484991,0.00002409531,0.0002307178,0.00004810096,0.8618226,0.00005768596],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7944429,0.181403,0.000001600471,0.0202874,0.000779725,0.002177289,0.0000460729,0.00001329963,0.0008486826],"genre_scores_gemma":[0.9323429,0.06450029,0.000318689,0.00006105762,0.0008591281,0.001503333,0.0001484029,0.00001122935,0.000254955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8521883,"threshold_uncertainty_score":0.1552743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06395084433925094,"score_gpt":0.4030367403447434,"score_spread":0.3390858960054924,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}