{"id":"W2044287047","doi":"10.3747/co.19.1281","title":"Targeting the Androgen Receptor in the Management of Castration-Resistant Prostate Cancer: Rationale, Progress, and Future Directions","year":2012,"lang":"en","type":"article","venue":"Current Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Enzalutamide; Prostate cancer; Medicine; Abiraterone acetate; Androgen receptor; Disease; Clinical trial; Abiraterone; Hormonal therapy; Cancer; Bioinformatics; Oncology; Cancer research; Pharmacology; Androgen deprivation therapy; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007642192,0.0009072424,0.001449477,0.001497026,0.0004623565,0.002133874,0.001708447,0.002665586,0.00273634],"category_scores_gemma":[0.002309727,0.0003780458,0.0006944448,0.001310964,0.00207027,0.00291789,0.0007206416,0.005648185,0.001166244],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001320013,"about_ca_system_score_gemma":0.003230998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001145636,"about_ca_topic_score_gemma":0.004105999,"domain_scores_codex":[0.9991278,0.0003654796,0.000114761,0.00008727088,0.0002184598,0.00008625242],"domain_scores_gemma":[0.9975619,0.00131457,0.0002669649,0.0000897194,0.0005282952,0.0002385502],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00111896,0.00129674,0.002241745,0.007273651,0.0001619366,0.001110013,0.0002304883,0.001958313,0.006479273,0.02048478,0.02088054,0.9367635],"study_design_scores_gemma":[0.001309496,0.008266093,0.006571984,0.01150537,0.0007947564,0.005745809,0.0009793792,0.003604739,0.006294789,0.03143316,0.9232644,0.0002299937],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002465516,0.9685763,0.002118754,0.02223615,0.0007866283,0.00007785192,0.00004690164,0.00004678349,0.003645146],"genre_scores_gemma":[0.01361231,0.9698696,0.006313701,0.005924824,0.002642995,0.0001081545,0.00009477992,0.00001535692,0.001418271],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.007642192,"threshold_uncertainty_score":0.0404163,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06395084433925094,"score_gpt":0.4030367403447434,"score_spread":0.3390858960054924,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}