{"id":"W2044399712","doi":"10.1074/jbc.m100093200","title":"Cross-talk between the p42/p44 MAP Kinase and Smad Pathways in Transforming Growth Factor β1-induced Furin Gene Transactivation","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":122,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Université de Sherbrooke","funders":"","keywords":"Transactivation; SMAD; MAPK/ERK pathway; Furin; Cell biology; Transcription factor; Transforming growth factor; Biology; Phosphorylation; Molecular biology; Signal transduction; Transfection; Chemistry; Gene; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002772866,0.0001956543,0.0002433194,0.0000244835,0.00008805011,0.00004165441,0.0002750143,0.0003201843,0.00005528285],"category_scores_gemma":[0.0001681222,0.000127186,0.0001531688,0.00008232254,0.0001066154,0.00001304245,0.00002989579,0.0003052916,8.213391e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003060235,"about_ca_system_score_gemma":0.0000701981,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005909631,"about_ca_topic_score_gemma":0.000001434964,"domain_scores_codex":[0.9988048,0.00005686867,0.000482843,0.0002425365,0.0001573441,0.0002556101],"domain_scores_gemma":[0.9993369,0.00007152506,0.0002121844,0.0001430296,0.00009538525,0.0001409725],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002256759,0.0000826233,0.06036506,0.00003047597,0.00003902616,0.00004246659,0.00004498956,0.000008265581,0.9364104,5.142715e-7,0.000003991433,0.002746549],"study_design_scores_gemma":[0.0007644373,0.0001802606,0.09289461,0.00003245631,0.00001497358,0.000085182,0.00005734717,0.000003301691,0.9052325,0.00007595115,0.0004994588,0.0001595139],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998201,0.000979755,0.0004323522,0.00015176,0.00003963274,0.00008968634,0.00003186674,0.000007681178,0.00006623923],"genre_scores_gemma":[0.9991192,0.000171614,0.0001261118,0.00006307106,0.0004474839,0.00000566004,0.00003493289,0.00001289271,0.0000189996],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03252954,"threshold_uncertainty_score":0.5186493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03487039384359169,"score_gpt":0.2681788346640109,"score_spread":0.2333084408204192,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}