{"id":"W2044518560","doi":"10.1038/ng.443","title":"Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia","year":2009,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":479,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal; McGill University; Diabetes Canada; McGill University and Génome Québec Innovation Centre","funders":"","keywords":"Hyperinsulinemia; Insulin resistance; Biology; Single-nucleotide polymorphism; IRS1; Type 2 diabetes; Insulin receptor; Genome-wide association study; Population; Internal medicine; Endocrinology; Genetics; Insulin; Genetic association; Diabetes mellitus; Gene; Medicine; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002112656,0.0002596506,0.0002886929,0.00003565894,0.0001658235,0.00004066771,0.0002094851,0.0007663726,0.00001633944],"category_scores_gemma":[0.000354862,0.0002307402,0.00004961837,0.0002452729,0.0001089521,0.000002342631,0.00006382596,0.0003380761,0.000006172064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002636457,"about_ca_system_score_gemma":0.0001387774,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001968275,"about_ca_topic_score_gemma":0.00004931071,"domain_scores_codex":[0.9984705,0.00009606765,0.0002850305,0.0005357659,0.0001742585,0.0004383982],"domain_scores_gemma":[0.998956,0.00003128794,0.0001647783,0.0004481672,0.0002598623,0.0001398886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007958733,0.0008561182,0.7036059,0.00009631804,0.001382758,0.0001348395,0.0008497306,0.002359991,0.1119724,0.0002058736,0.1290358,0.04870429],"study_design_scores_gemma":[0.001040765,0.0008720988,0.9151571,0.00002793817,0.00009040037,0.00001629118,0.00001939649,0.0006525887,0.003117392,0.0004036554,0.0781478,0.000454598],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9769008,0.02091934,0.0001456518,0.0009058702,0.0001491943,0.0001944551,0.00004720362,0.00002226292,0.0007152748],"genre_scores_gemma":[0.9727012,0.002666984,0.01978616,0.003751405,0.000221363,0.000006265257,0.0001284976,0.00003095511,0.0007071761],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2115511,"threshold_uncertainty_score":0.9409312,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004817587405573285,"score_gpt":0.2247904397365719,"score_spread":0.2199728523309986,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}