{"id":"W2044518560","doi":"10.1038/ng.443","title":"Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia","year":2009,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":479,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal; McGill University; Diabetes Canada; McGill University and Génome Québec Innovation Centre","funders":"","keywords":"Hyperinsulinemia; Insulin resistance; Biology; Single-nucleotide polymorphism; IRS1; Type 2 diabetes; Insulin receptor; Genome-wide association study; Population; Internal medicine; Endocrinology; Genetics; Insulin; Genetic association; Diabetes mellitus; Gene; Medicine; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007741481,0.001352495,0.0007687287,0.002129808,0.0009760909,0.000722827,0.0008559414,0.00158805,0.00445086],"category_scores_gemma":[0.002502994,0.0006319143,0.000959506,0.002263537,0.0006385898,0.0003673151,0.000461316,0.001524253,0.0005321116],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002604848,"about_ca_system_score_gemma":0.0002336664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00193914,"about_ca_topic_score_gemma":0.00112694,"domain_scores_codex":[0.9991949,0.0002872207,0.0001097157,0.0002093159,0.0001303309,0.00006852729],"domain_scores_gemma":[0.9975519,0.000921419,0.0008144742,0.0001763029,0.0001407415,0.0003951899],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01066358,0.0009679966,0.8945504,0.0001666665,0.00182493,0.01485712,0.000715049,0.000600495,0.06506275,0.0007131966,0.0008105639,0.009067221],"study_design_scores_gemma":[0.0002518003,0.000764281,0.9726433,0.00004859912,0.0008603661,0.01832433,0.0002840785,0.001880277,0.003490746,0.0006037476,0.0007933067,0.00005514833],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981944,0.0002838724,0.0004373997,0.0001402095,0.00004475523,0.000009084991,0.0001720884,0.00002655397,0.0006916621],"genre_scores_gemma":[0.9982292,0.0001173214,0.0005575313,0.00005429182,0.00006429844,0.000009073074,0.000161586,0.00001650379,0.0007902725],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00445086,"threshold_uncertainty_score":0.0148896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004817587405573285,"score_gpt":0.2247904397365719,"score_spread":0.2199728523309986,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}